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CRABP2 Antibody

  • 货号：
    CSB-PA001777
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HT29 cells using CRABP-II Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P29373
  • 基因名：
    CRABP2
  • 别名：
    Cellular retinoic acid binding protein 2 antibody; Cellular retinoic acid binding protein II antibody; Cellular retinoic acid-binding protein 2 antibody; Cellular retinoic acid-binding protein II antibody; CRABP II antibody; CRABP-II antibody; Crabp2 antibody; CRABPII antibody; RABP2_HUMAN antibody; RBP6 antibody; Rretinoic acid-binding protein, cellular, type II antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CRABP-II.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
  • 基因功能参考文献：
    1. Semiquantitative and quantitative analyses of the markers RARA and CRABP2 indicate their potential as biomarkers for tumor progression and their participation in nephroblastoma tumorigenesis PMID: 29378601
    2. These data suggest a retinoic acid-independent, non-tumor suppressor role of CRABP2 for the survival of Malignant peripheral nerve sheath tumor (MPNST) cells in vitro. Targeting CRABP2 overexpression may represent a unique approach for the treatment of human MPNST. PMID: 28502478
    3. A high expression ratio between FABP5 and CRABPII may be related to CP tumor recurrence and ATRA could be a potential therapeutic agent for CP chemotherapy. PMID: 27418530
    4. reducing CRABP2 levels may enhance the therapeutic index of Retinoic acid in glioblastoma multiforme patients PMID: 26893190
    5. in esophageal squamous carcinogenesis by significantly inhibiting cell growth, inducing cell apoptosis and blocking cell metastasis both in vitro and in vivo PMID: 26839961
    6. The anticarcinogenic activities of CRABP2 are mediated by both HuR and RAR. PMID: 25320093
    7. CBX3 and CRABP2 expression was markedly increased in lung cancer tissues PMID: 24751108
    8. Reengineering of cellular retinoic acid binding protein II (CRABPII) to be capable of binding retinal as a protonated Schiff base is described PMID: 24059243
    9. CRABP2 controls mRNA stabilization by HuR. PMID: 24687854
    10. overexpression of CRABP-II is a late event of pancreatic carcinogenesis, and it could be used as a diagnostic marker PMID: 24709110
    11. all three proteins (RDH10, RALDH2, and CRABP2) appeared to be required for ATRA production induced by activation of PPARgamma PMID: 23833249
    12. E-FABP showed high exp ression in NSCLC, and the increased E-FABP expression may involved in the occurrence and development of NSCLC PMID: 23327868
    13. Hypermethylation in the CpG island of the CRABP2 gene is associated with astrocytic gliomas. PMID: 22275178
    14. Aberrant methylation in CRABP-II reduces the expression of CRABP-II that in turn confers retinoic acid resistance in medulloblastoma cells. PMID: 22153617
    15. Low CRABP2 is associated with pancreatic ductal adenocarcinoma. PMID: 22010213
    16. Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation PMID: 21998312
    17. Trophoblast spheroids cocultured with endometrial cells overexpressing CRABP2 are defective in expansion and exhibit apoptosis, suggesting that CRABP2 is involved in abnormal endometrium-trophoblast interaction, leading to implantation failure. PMID: 21605859
    18. Data show that NIPER-4 induces cIAP1-mediated ubiquitylation of CRABP-II, resulting in the proteasomal degradation. PMID: 21414315
    19. Individual variation in ALDH1A2/CRABP2 genes may account for subtle variations in retinoic acid-dependent human embryogenesis. PMID: 20308937
    20. Data sghow a higher frequency of CRABP2 and MX1 hypermethylation in primary HNSCC when compared with lymphocytes from healthy individuals. PMID: 20019841
    21. Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest. PMID: 11909957
    22. Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of this protein PMID: 12482873
    23. In this study, we excluded mutations within the complete coding region and the promoter of LMNA and the CRABP II gene in HIV-1 infected patients with lipodystrophy PMID: 12844477
    24. CRABP-II has a role in wound re-epithelialisation by dermal fibroblasts PMID: 14766225
    25. Phosphorylation/dephosphorylation of retinoic x receptor alpha via protein kinase C may be involved in the regulation of CRABP-II gene expression. PMID: 15225641
    26. Data suggest that the ligand-controlled nuclear localization signal of CRABP-II may represent a general mechanism for posttranslational regulation of the subcellular distribution of a protein. PMID: 15866176
    27. Transient transfection of either all-trans-retinoic acid (ATRA) receptor alpha or estrogen receptor alpha expression vectors increased CRABPII expression in MDA-MB-231 cells PMID: 15870697
    28. CRABP-II overexpression in CAKI-2 RCC cells did not significantly influence RA associated antiproliferative actions. PMID: 16215318
    29. MycN binds to the promoter of CRABP-II and induces CRABP-II transcription directly in neuroblastoma. PMID: 16912187
    30. Results describe the structure of apo-wild type (WT) CRABPII at 1.35 A and show that apo- and holo-CRABPII share very similar structures. PMID: 16979656
    31. AP2 factors regulate CRABPII expression in human mammary epithelial cells and breast cancer cells PMID: 17187826
    32. results show that the CRABP2 gene is associated with increased plasma LDL-C concentrations. Carriers of the C allele had significantly higher LDL-C in healthy males, HIV-infected patients, and patients with familial hypercholesterolemia PMID: 17484622
    33. Retinoic acid and retinol regulate expression of cellular retinol binding protein 1 and cellular RA binding protein 2 in fibroid and myometrial cells. PMID: 18343808
    34. MycN and DNA methylation are responsible for CRABP-II expression in pediatric tumors and demethylation of CRABP-II may be an early event in tumor development. PMID: 18955045
    35. Derangement/lack of a critical factor necessary for RARalpha function induces epigenetic repression of a RA-regulated gene network downstream of RARalpha, with major pleiotropic biological outcomes. PMID: 19173001

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  • 亚细胞定位：
    Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
  • 蛋白家族：
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 数据库链接：

    HGNC: 2339

    OMIM: 180231

    KEGG: hsa:1382

    STRING: 9606.ENSP00000357204

    UniGene: Hs.405662