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CPT1C Antibody

  • 货号：
    CSB-PA855048LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, Mouse liver tissue, Mouse lung tissue
      All lanes: CPT1C antibody at 2.6µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 91, 90, 81 kDa
      Observed band size: 91 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA855048LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA855048LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CPT1C Polyclonal antibody
  • Uniprot No.：
    Q8TCG5
  • 基因名：
  • 别名：
    brain isoform antibody; Carnitine acyltransferase like protein 1 antibody; Carnitine acyltransferase like protein1 antibody; Carnitine O palmitoyltransferase 1 brain isoform antibody; Carnitine O palmitoyltransferase I; brain isoform antibody; Carnitine O-palmitoyltransferase 1 antibody; Carnitine O-palmitoyltransferase I antibody; Carnitine palmitoyltransferase 1; brain antibody; Carnitine palmitoyltransferase 1C antibody; Carnitine palmitoyltransferase I related C antibody; Carnitine palmitoyltransferase1C antibody; CAT L1 antibody; CATL 1 antibody; CATL1 antibody; CPT 1 like pseudogene antibody; Cpt 1c antibody; CPT 1P antibody; CPT I C antibody; CPT IC antibody; Cpt1 c antibody; CPT1 like pseudogene antibody; CPT1-B antibody; Cpt1c antibody; CPT1C_HUMAN antibody; CPT1P antibody; CPTI-B antibody; CPTIC antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Carnitine O-palmitoyltransferase 1, brain isoform protein (699-803AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CPT1C Antibody (CSB-PA855048LA01HU)，的标记方式是Non-conjugated。对于CPT1C Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA855048LB01HU CPT1C Antibody, HRP conjugated ELISA
    FITC CSB-PA855048LC01HU CPT1C Antibody, FITC conjugated
    Biotin CSB-PA855048LD01HU CPT1C Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in lipid metabolic process.
  • 基因功能参考文献：
    1. Depletion of PPARalpha resulted in low CPT1C expression. PMID: 28334197
    2. CPT1C binds malonyl-CoA and long-chain acyl-CoA suggest that it is a sensor of lipid metabolism in neurons, where it appears to impact ceramide and triacylglycerol metabolism. [review] PMID: 26708865
    3. CPT1c is found in brain regions that are related to food intake and neuropsychiatric disease. CPT1c affects ceramide levels, endocannabionoids, and oxidative processes and may play an important role in various brain functions such as learning. PMID: 26041663
    4. CPT1C mutation associated with novel form of pure autosomal dominant hereditary spastic paraplegia. PMID: 25751282
    5. High grade glioblastoma is associated with increased level of ZFP57, a protein involved in gene imprinting, and aberrant expression of CPT1A and CPT1C. PMID: 24618825
    6. Data suggest that an involvement of CPT1C in cellular energy-sensing pathways and provide evidence for a role of CPT1C in hypothalamic regulation of energy homeostasis. PMID: 21961029
    7. cells can use a novel mechanism involving CPT1C and fatty acid metabolism to protect against metabolic stress PMID: 21576264
    8. CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity PMID: 18192268
    9. Accumulation of 3-hydroxylated intermediates of long-chain fatty acids may contribute to the pathogenesis of retinopathy in MTP deficiencies. PMID: 18385088

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  • 相关疾病：
    Spastic paraplegia 73, autosomal dominant (SPG73)
  • 亚细胞定位：
    Mitochondrion outer membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite. Cell projection, axon. Endoplasmic reticulum.
  • 蛋白家族：
    Carnitine/choline acetyltransferase family
  • 组织特异性：
    Expressed predominantly in brain and testis. Expressed in motor neurons.
  • 数据库链接：

    HGNC: 18540

    OMIM: 608846

    KEGG: hsa:126129

    STRING: 9606.ENSP00000319343

    UniGene: Hs.112195