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CPM Antibody

  • 货号：
    CSB-PA005897ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CPM Polyclonal antibody
  • Uniprot No.：
    P14384
  • 基因名：
    CPM
  • 别名：
    Carboxypeptidase M antibody; CBPM_HUMAN antibody; CPM antibody; Renal carboxypeptidase antibody; Urinary carboxypeptidase B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Carboxypeptidase M protein (204-443AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.
  • 基因功能参考文献：
    1. Low CPM expression is associated with colorectal cancer. PMID: 28186967
    2. CPM binding to extracellular loop 2 of the B1R results in positive allosteric modulation of B1R signaling, and disruption of this interaction could provide a novel therapeutic approach to reduce pathological B1R signaling. PMID: 24108126
    3. Carboxypeptidase M expression is lost in human renal cell carcinoma tumor cells, whereas it is abundant in tumor-associated foam cells and neovasculature. PMID: 23172796
    4. novel marker and cellular player in lipid uptake and/or metabolism of activated macrophages by promoting foam cell formation PMID: 22157720
    5. CPM and B1Rs on cell membranes form a critical complex that potentiates B1R signaling. PMID: 21454694
    6. CPM amplification could be used as an alternative diagnostic tool for the diagnosis of well-differentiated liposarcoma/atypical lipomatous tumors. PMID: 19820690
    7. Results report the crystallization of human carboxypeptidase M and its 3.0 angstrom crystal structure. PMID: 15066430
    8. Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient b1 signaling from B2 agonists PMID: 18187413
    9. Cleavage of the C-terminal lysine residue of SDF-1alpha by CPM leads to attenuated chemotactic responses. PMID: 18292211
    10. Multiple transcription start sites in two regions ~30 kb apart are flanked by two unique functional promoters. Five major types of transcripts resulting from multiple transcription start sites and alternate splicing in the 5-prime region were identified. PMID: 11891060
    11. CPM is membrane-bound via attachment of glycosylphosphatidylinositol at Ser406. Glu264 is a critical catalytic residue, whereas Glu260 affects stability and substrate kinetics. PMID: 12457462

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Peptidase M14 family
  • 数据库链接：

    HGNC: 2311

    OMIM: 114860

    KEGG: hsa:1368

    STRING: 9606.ENSP00000339157

    UniGene: Hs.654387