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CPLX2 Antibody

  • 货号：
    CSB-PA761369ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Complexin-2 antibody at 6μg/ml
      Lane 1: Rat brain tissue
      Lane 2: A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 15 kDa
      Observed band size: 15 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CPLX2 Polyclonal antibody
  • Uniprot No.：
    Q6PUV4
  • 基因名：
  • 别名：
    921 L antibody; Complexin 2 antibody; Complexin II antibody; Complexin-2 antibody; Complexin2 antibody; ComplexinII antibody; CPLX 2 antibody; Cplx2 antibody; CPLX2_HUMAN antibody; CPX 2 antibody; CPX II antibody; CPXII antibody; Hfb1 antibody; Synaphin 1 antibody; Synaphin-1 antibody; Synaphin1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Complexin-2 protein (1-134AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis.
  • 基因功能参考文献：
    1. This study demonstrated that complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease. PMID: 27866231
    2. Then results indicated that CPLX2 may be involved in the etiology of schizophrenia and one of its potential biological mechanisms by studying the effects of CPLX2 risk variants on working memory load-dependent neural activity in a frontoparietal network. PMID: 25297695
    3. These results suggested that CPLX2 participated in synaptic taste transduction. PMID: 25692331
    4. CPLX2 rs1366116*T variant represents a risk factor of schizophrenia, and , at the same time, CPLX2 rs3892909*T variant is protective against schizophrenia (study performed in Armenians). PMID: 25564026
    5. role in synaptic vesicle exocytosis PMID: 12058476
    6. altered immunoreactivity of this protein in prefrontal cortex in severe mental illness PMID: 12082566
    7. in huntingtin mutation, the decline in neurotransmitter release is a direct consequence of complexin II depletion PMID: 12807877
    8. In schizophrenia, complexin II was reduced in dorsolateral prefrontal cortex and superior temporal cortex. The impairment of synaptic transmission may contribute to the dysfunction of cortical neural circuits that characterises the disorder. PMID: 15653259
    9. CX2 level increased between the fetal and the 6-10 years groups and then plateaued PMID: 18240322

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  • 亚细胞定位：
    Cytoplasm, cytosol. Cell junction, synapse, presynapse. Nucleus. Perikaryon.
  • 蛋白家族：
    Complexin/synaphin family
  • 组织特异性：
    Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with sc
  • 数据库链接：

    HGNC: 2310

    OMIM: 605033

    KEGG: hsa:10814

    STRING: 9606.ENSP00000352544

    UniGene: Hs.193235