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CPEB4 Antibody

  • 货号：
    CSB-PA618177LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of Hela cells with CSB-PA618177LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Western blot
      All lanes: CPEB4 antibody at 2µg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: 293T whole cell lysate
      Lane 3: U87 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 81, 79, 37 kDa
      Observed band size: 81 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CPEB4 Polyclonal antibody
  • Uniprot No.：
    Q17RY0
  • 基因名：
    CPEB4
  • 别名：
    CPE binding protein 4 antibody; CPE-binding protein 4 antibody; CPE-BP4 antibody; cpeb4 antibody; CPEB4_HUMAN antibody; Cytoplasmic polyadenylation element binding protein 4 antibody; Cytoplasmic polyadenylation element-binding protein 4 antibody; hCPEB-4 antibody; KIAA1673 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cytoplasmic polyadenylation element-binding protein 4 protein (244-515AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CPEB4 Antibody (CSB-PA618177LA01HU)，的标记方式是Non-conjugated。对于CPEB4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA618177LB01HU CPEB4 Antibody, HRP conjugated ELISA
    FITC CSB-PA618177LC01HU CPEB4 Antibody, FITC conjugated
    Biotin CSB-PA618177LD01HU CPEB4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited. Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation. Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT. Stimulates proliferation of melanocytes. In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory.
  • 基因功能参考文献：
    1. Silencing of CPEB4 induces reactive oxygen species generation, thus suppressing the Akt expression, which finally prevents non-small cell lung cancer cells invasion and migration. PMID: 29286212
    2. This study identified a lineage-specific requirement of CPEB4 in malignant melanoma. PMID: 27857118
    3. Survival analysis revealed a significant association between progression free survival (PFS) and overall survival (OS) and CPEB4 immunohistochemical expression, which was independent in the multivariate analysis. CPEB4 behaves as a significant predictor of prognosis in stage IV colorectal carcinoma. PMID: 28551384
    4. The results implicate the potential role of CPEB4 and Vimentin in breast cancer metastasis, which is further confirmed by the finding that there is a physical interaction between the two proteins. PMID: 28536077
    5. CPEB4 and IRF4 expression in peripheral mononuclear cells are potential prognostic factors for advanced lung cancer PMID: 27113098
    6. downregulation of CPEB4 likely occurs at the late cancer stage to facilitate HCC progression. Biphasic alteration of CPEB4 expression during HCC progression suggests its complicated role in tumorigenesis PMID: 27158894
    7. positive cytoplasmic polyadenylation element binding protein 4 expression predicted a worse prognosis in glioma patients, and cytoplasmic polyadenylation element binding protein 4 could represent a useful biomarker or therapeutic target for glioma. PMID: 28381179
    8. high expression of CPEB4 was found to be an independent prognostic biomarker for overall survival in colorectal cancer patients PMID: 27771769
    9. Our studies first validated that CPEB4 interacts with Vimentin and indicated that high CPEB4 expression in astrocytic tumors correlates closely with a clinically aggressive future, and that CPEB4 might represent a valuable prognostic marker for patients with astrocytic tumors. PMID: 26546435
    10. Low CPEB4 expression and high CPEB1 expression were independent predictors of overall survival in glioma patients. PMID: 27000226
    11. findings imply that posttranscriptional deregulation of CPEB4 contributes to the inhibited cell proliferation and the enhanced cell apoptosis in colorectal cancer, and directly targeting CPEB4 by miR-203 might be a strategy in colorectal cancer treatment PMID: 26361147
    12. Evidence that CPEB4 uses both its RNA recognition motifs to maintain optimal RNA binding. PMID: 25081215
    13. CPEB4 is a candidate biomarker for defining metastatic cancers and directing personalized therapies. PMID: 24045092
    14. Knockdown of CPEB4 expression significantly facilitated HCC cell migration and invasion. PMID: 23145039
    15. CPEB4, an RNA binding protein that mediates meiotic mRNA cytoplasmic polyadenylation and translation, is overexpressed in pancreatic ductal adenocarcinomas and glioblastomas, where it supports tumor growth, vascularization and invasion. PMID: 22138752

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  • 亚细胞定位：
    Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density. Cell projection, axon. Cell projection, growth cone. Endoplasmic reticulum. Cytoplasm, perinuclear region.
  • 蛋白家族：
    RRM CPEB family
  • 组织特异性：
    Expressed in pancreas in islets and ductal cells (at protein level). Expressed in melanocytes.
  • 数据库链接：

    HGNC: 21747

    OMIM: 610607

    KEGG: hsa:80315

    STRING: 9606.ENSP00000265085

    UniGene: Hs.127126