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COX7A1 Antibody

  • 货号：
    CSB-PA005860GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P24310
  • 基因名：
  • 别名：
    COX7A antibody; COX7A1 antibody; COX7AH antibody; COX7AM antibody; CX7A1_HUMAN antibody; Cytochrome c oxidase subunit 7A1 antibody; Cytochrome c oxidase subunit 7A1 mitochondrial antibody; Cytochrome c oxidase subunit VIIa H antibody; Cytochrome c oxidase subunit VIIa heart antibody; Cytochrome c oxidase subunit VIIa heart/muscle isoform antibody; Cytochrome c oxidase subunit VIIa M antibody; Cytochrome c oxidase subunit VIIa muscle antibody; Cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) antibody; Cytochrome c oxidase subunit VIIa polypeptide 1 antibody; Cytochrome c oxidase subunit VIIa-H antibody; Cytochrome c oxidase subunit VIIa-heart antibody; Cytochrome c oxidase subunit VIIa-M antibody; Cytochrome c oxidase subunit VIIa-muscle antibody; mitochondrial antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human COX7A1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
  • 基因功能参考文献：
    1. COX7A1 is a novel gene that might play a crucial role in the etiology of lung adenocarcinoma and can serve as a biomarker for lung cancer disease progression PMID: 27866983
    2. promoter contains and is regulated by sequence elements typical of contractile muscle as well as the element for the common transcription factor Sp1 PMID: 11997101
    3. While DNA methylation of the COX7A1 promoter was increased in muscle from elderly compared with young twins, the opposite was found for COX7A1 mRNA expression PMID: 18488190
  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    Cytochrome c oxidase VIIa family
  • 数据库链接：

    HGNC: 2287

    OMIM: 123995

    KEGG: hsa:1346

    STRING: 9606.ENSP00000292907

    UniGene: Hs.421621