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COX10 Antibody

  • 货号：
    CSB-PA257877
  • 规格：
    ￥1100
  • 图片：
    • The image is immunohistochemistry of paraffin-embedded Human renal cancer tissue using CSB-PA257877(COX10 Antibody) at dilution 1/100. (Original magnification: 200)
  • 其他：

产品详情

  • Uniprot No.：
    Q12887
  • 基因名：
  • 别名：
    2410004F01Rik antibody; AU042636 antibody; COX10 antibody; COX10_HUMAN antibody; Cytochrome c oxidase assembly protein antibody; Cytochrome c oxidase subunit X antibody; Heme A farnesyltransferase antibody; Heme O synthase antibody; OTTMUSP00000006085 antibody; Protoheme IX farnesyltransferase; mitochondrial antibody; Protoheme IX farnesyltransferase; mitochondrial precursor antibody; RP23-78H18.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human COX10
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Converts protoheme IX and farnesyl diphosphate to heme O.
  • 基因功能参考文献：
    1. On the basis of its pivotal role in regulating cell death upon COX dysfunction, CerS6 might potentially represent a novel target for therapeutic intervention in mitochondrial diseases caused by COX dysfunction. PMID: 25766330
    2. ISCU and COX10 are target genes of miR-210 related to mitochondrial metabolism PMID: 20498629
    3. COX 15 mRNA was significantly more abundant in the cerebral tissue of Alzheimer's disease (AD) patients and COX10 and COX15 SNP were significantly less represented in the patient group, suggesting a possible protective role toward the risk for AD PMID: 19826901
    4. The expression of the AOX, well-tolerated by the cells, compensates for both the growth defect and the pronounced oxidant-sensitivity of COX-deficient human cells. PMID: 20049701
    5. Cytochrome c oxidase is decreased significantly in platelets and hippocampus in Alzheimer patients compared to controls. PMID: 11959398
    6. COX10 has a role in mitochondrial heme A biosynthesis PMID: 12928484
    7. This study report a cytochrome c oxidase (COX)-deficient patient, clinically affected with Leigh-like disease, with a homozygous mutation in the COX10 start codon. PMID: 15455402
    8. Geranylgeranyltransferase inhibitor-2147 (GGTI-2147), an inhibitor of this enzyme prenylation, elicited significant inhibition of glucose-stimulated insulin secretion from INS 832/13 islet cells. PMID: 17192483

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  • 相关疾病：
    Mitochondrial complex IV deficiency (MT-C4D); Leigh syndrome (LS)
  • 亚细胞定位：
    Mitochondrion membrane; Multi-pass membrane protein.
  • 蛋白家族：
    UbiA prenyltransferase family
  • 数据库链接：

    HGNC: 2260

    OMIM: 220110

    KEGG: hsa:1352

    STRING: 9606.ENSP00000261643

    UniGene: Hs.462278