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CORO7 Antibody

  • 货号：
    CSB-PA005819LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CORO7 Polyclonal antibody
  • Uniprot No.：
    P57737
  • 基因名：
    CORO7
  • 别名：
    0610011B16Rik antibody; 70 kDa WD repeat tumor rejection antigen homolog antibody; CORO 7 antibody; Coro7 antibody; CORO7_HUMAN antibody; Coronin-7 antibody; Coronin7 antibody; Crn7 antibody; FLJ22021 antibody; FLJ44188 antibody; POD1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Coronin-7 protein (630-900AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CORO7 Antibody (CSB-PA005819LA01HU)，的标记方式是Non-conjugated。对于CORO7 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA005819LB01HU CORO7 Antibody, HRP conjugated ELISA
    FITC CSB-PA005819LC01HU CORO7 Antibody, FITC conjugated
    Biotin CSB-PA005819LD01HU CORO7 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
  • 基因功能参考文献：
    1. Obese children had significantly lower methylation levels at a CpG site located near coronin 7 (CORO7), which encodes a tryptophan-aspartic acid dipeptide (WD)-repeat containing protein most likely involved in Golgi complex morphology and function PMID: 25887538
    2. Results show that enforced targeting of Crn7 to TGN 9trans-Golgi network) bypasses the requirement of K33-ubiquitination for TGN-pool F-actin assembly and post-Golgi trafficking. PMID: 24768539
    3. Data show that CRN7 interacted with Cullin1 and Roc1 to form a novel SCF-like E3 complex. PMID: 21130766
    4. role in the organization of intracellular membrane compartments and vesicular trafficking rather than in remodeling the cytoskeleton PMID: 15327992
    5. Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi PMID: 16905771
    6. Sequential events of protein interaction and posttranslational modification result in the membrane targeting of Crn7. PMID: 18581049

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  • 亚细胞定位：
    Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle. Cytoplasm, cytosol. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.
  • 蛋白家族：
    WD repeat coronin family
  • 组织特异性：
    Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine.
  • 数据库链接：

    HGNC: 26161

    OMIM: 611668

    KEGG: hsa:79585

    STRING: 9606.ENSP00000460885

    UniGene: Hs.437957