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CORO1C Antibody

  • 货号：
    CSB-PA782311
  • 规格：
    ￥1100
  • 图片：
    • The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA782311(CORO1C Antibody) at dilution 1/50. (Original magnification: ×200)
    • The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA782311(CORO1C Antibody) at dilution 1/50. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Lovo cells, Primary antibody: CSB-PA782311(CORO1C Antibody) at dilution 1/530, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q9ULV4
  • 基因名：
    CORO1C
  • 别名：
    COR1C_HUMAN antibody; CORO 1C antibody; Coro1c antibody; Coronin 1c antibody; Coronin actin binding protein 1C antibody; Coronin-1C antibody; Coronin-3 antibody; Coronin1c antibody; Coronin3 antibody; CRNN 4 antibody; CRNN4 antibody; HCRNN 4 antibody; hCRNN4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human CORO1C
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1. Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. Required for normal cell proliferation, cell migration, and normal formation of lamellipodia. Required for normal distribution of mitochondria within cells.; Involved in myogenic differentiation.
  • 基因功能参考文献：
    1. Coronin 1c protein and F-actin protein are highly expressed in breast cancer and their expression may be related to the metastasis of breast cancer cells. PMID: 30150608
    2. circBIRC6 and circCORO1C are functionally associated with the pluripotent state in undifferentiated human embryonic stem cells PMID: 29074849
    3. It would appear that YB-1 could regulate cell invasion and migration via downregulation of its indirect target coronin-1C. The association between YB-1 and coronin-1C offers a novel approach by which metastasis of breast cancer cells could be targeted and abrogated. PMID: 28302118
    4. findings emphasize the power of genetic modifiers, PLS3 and CORO1C, to unravel the cellular pathomechanisms underlying spinal muscular atrophy (SMA)--and the power of combinatorial therapy based on splice correction of SMN2 and endocytosis improvement to efficiently treat SMA PMID: 27499521
    5. Data indicate that coronin 1C protein (CORO1C) was a direct target of the microRNA miR-1/133a cluster in EBC-1 CORO1C was a direct target of the miR-1/133a cluster in lung-squamous cell carcinoma cell line EBC-1. PMID: 25518741
    6. Coro1C mediated Rac1 trafficking through actin-rich vesicles. PMID: 25862165
    7. Coronin-1C overexpression is associated withand hepatocellular carcinoma growth through enhancement of tumor cell proliferation and migration, which are correlated with Rac-1 activation. PMID: 23292607
    8. Coronin 3 promotes gastric cancer metastasis via the up-regulation of MMP-9 and cathepsin K. PMID: 22974233
    9. Patients with higher coronin-1C expression had a more advanced stage of hepatocellular carcinoma. PMID: 20678442
    10. There is a strong expression of both SELPLG and coronin-1C in the majority of primary effusion lymphomas, irrespective of their gene dosage. SELPLG is critical for cell migration and chemotaxis, while CORO1C regulates actin-dependent processes. PMID: 20690162
    11. Coronin 1C negatively regulates epithelial cell migration via FAK-mediated inhibition of cell-matrix adhesion. PMID: 19913511
    12. oligomerization, F-actin interaction and membrane association are mediated by carboxyl terminus PMID: 12377779
    13. Fndings postulate a role for CRN2 isoforms in the structural and functional organization of F-actin in highly ordered protein complexes. PMID: 19651142

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Endosome membrane.; [Isoform 3]: Cell membrane, sarcolemma. Cytoplasm, myofibril, sarcomere. Cell junction, synapse. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
  • 蛋白家族：
    WD repeat coronin family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 2254

    OMIM: 605269

    KEGG: hsa:23603

    STRING: 9606.ENSP00000261401

    UniGene: Hs.330384