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COPS8 Antibody

  • 货号：
    CSB-PA005796GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q99627
  • 基因名：
    COPS8
  • 别名：
    COP9 homolog antibody; COP9 signalosome complex subunit 8 antibody; COP9 signalosome subunit 8 antibody; Cops8 antibody; CSN8 antibody; CSN8_HUMAN antibody; hCOP9 antibody; JAB1 containing signalosome subunit 8 antibody; JAB1-containing signalosome subunit 8 antibody; SGN8 antibody; Signalosome subunit 8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human COPS8
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 基因功能参考文献：
    1. Among 479 individuals affected with clear cell renal cell carcinoma, only synonymous variants were found in COPS8 and one of the missense variants in ACKR3:c.892C>T, was observed in 4/479 individuals screened PMID: 28063109
    2. Data indicate that silencing of Csn8 caused an increased growth rate, whereas silencing of Csn5 impaired proliferation in HeLa cells. PMID: 23689509
    3. miR-146a expression is up-regulated in a majority of gastric cancers where it targets CARD10 and COPS8, inhibiting GPCR-mediated activation of NF-kappaB. PMID: 22992343
    4. proteomic-based approach can broaden our understanding of the functions of the CSN in contexts such as viral-host interactions or immune activation in their natural milieu PMID: 22414063
    5. analysis of the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3 PMID: 20399188
    6. DDB2 and CSA are each integrated into nearly identical complexes via interaction with DDB1. Both complexes contain cullin 4A and Roc1 and display ubiquitin ligase activity. They also contain the COP9 signalosome (CSN) PMID: 12732143
    7. The COP9 signalosome (CSN) controls NF-kappaB by deubiquitinylation of IkappaBalpha. PMID: 17318178
    8. COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination PMID: 18424433

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSN8 family
  • 数据库链接：

    HGNC: 24335

    OMIM: 616011

    KEGG: hsa:10920

    STRING: 9606.ENSP00000346340

    UniGene: Hs.531713