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COPS7A Antibody

  • 货号：
    CSB-PA880068ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: COP9 signalosome complex subunit 7a antibody at 4μg/ml
      Lane 1: Rat heart tissue
      Lane 2: Rat brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 30 kDa
      Observed band size: 30 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA880068ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA880068ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) COPS7A Polyclonal antibody
  • Uniprot No.：
    Q9UBW8
  • 基因名：
    COPS7A
  • 别名：
    COP9 complex subunit 7a antibody; COP9 constitutive photomorphogenic homolog subunit 7A antibody; COP9 signalosome complex subunit 7a antibody; COP9 signalosome subunit 7A antibody; COPS7A antibody; CSN7A antibody; CSN7A_HUMAN antibody; Dermal papilla derived protein 10 antibody; Dermal papilla-derived protein 10 antibody; DERP10 antibody; JAB1 containing signalosome subunit 7a antibody; JAB1-containing signalosome subunit 7a antibody; SGN7a antibody; Signalosome subunit 7a antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human COP9 signalosome complex subunit 7a protein (1-275AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSN7/EIF3M family, CSN7 subfamily
  • 组织特异性：
    Widely expressed. Expressed at high level in brain, heart and skeletal muscle.
  • 数据库链接：

    HGNC: 16758

    OMIM: 616009

    KEGG: hsa:50813

    STRING: 9606.ENSP00000229251

    UniGene: Hs.530823