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COL19A1 Antibody

  • 货号：
    CSB-PA213241
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemistry analysis of paraffin-embedded human thymus gland tissue using Collagen XIX α1 antibody.
    • Immunofluorescence analysis of A549 cells, using Collagen XIX α1 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) COL19A1 Polyclonal antibody
  • Uniprot No.：
    Q14993
  • 基因名：
    COL19A1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human Collagen XIX α1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC,IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.
  • 基因功能参考文献：
    1. Naturally occurring interruptions in nonfibrillar collagen play key roles in molecular flexibility, collagen degradation, and ligand binding. This study focused on a G5G type natural interruption sequence G-POALO-G from human type XIX collagen, a homotrimer collagen, as this sequence possesses distinct properties compared with those of a pathological similar Gly mutation sequence in collagen mimic peptides. PMID: 29376320
    2. Type XIX collagen is a new partner in the interactions between tumor cells and their microenvironment. (Review) PMID: 27491275
    3. collagen IX has unique cell adhesion properties when compared with other collagens, and it provides a novel mechanism for cell adhesion to cartilaginous matrix PMID: 15383545
    4. The NC2 domain of collagen XIX and probably of other FACITs is responsible for chain selection and trimerization PMID: 18845531
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibril-associated collagens with interrupted helices (FACIT) family
  • 组织特异性：
    Localized to vascular, neuronal, mesenchymal, and some epithelial basement membrane zones in umbilical cord.
  • 数据库链接：

    HGNC: 2196

    OMIM: 120165

    KEGG: hsa:1310

    STRING: 9606.ENSP00000316030

    UniGene: Hs.444842