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COL16A1 Antibody

  • 货号：
    CSB-PA005723GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q07092
  • 基因名：
    COL16A1
  • 别名：
    447AA antibody; Alpha 1 type XVI collagen antibody; COGA1_HUMAN antibody; Col16a1 antibody; Collagen alpha-1(XVI) chain antibody; Collagen; type XVI; alpha 1 antibody; FP1572 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human COL16A1-Specific
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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靶点详情

  • 功能：
    Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology.
  • 基因功能参考文献：
    1. The NC11 domain of collagen XVI is a potential biomarker for oral squamous cell carcinoma and triggers vasculogenic mimicry via upregulation of endothelial receptors VEGFR1, VEGFR2 and uPAR. PMID: 26424749
    2. High Collagen XVI expression is associated with invasion of oral squamous cell carcinoma. PMID: 24466237
    3. collagen XVI plays a decisive role in the interaction of connective tissue cells with their ECM, which is impaired in pathological situations PMID: 23149016
    4. Gene expression profiles showed that COL16A1 was up-regulated in epidermolysis bullosa subtypes. PMID: 22716248
    5. Overexpression of type XVI collagen in aberrant oral keratinocytes leads to Kindlin-1 induction, increased Kindlin-1/beta1-integrin interaction, integrin activation and subsequently to a proliferative cellular phenotype. PMID: 21251976
    6. Collagen XVI promotes persistence of intestinal subepithelial myofibroblasts in the normal and in the inflamed bowel wall by stabilizing focal adhesion contacts. PMID: 19931388
    7. Not in banded collagen fibrils in dermis, but is component of specialized fibrillin-1-containing microfibrils. In cartilage matrix not in aggregates with fibrillin-1. Resides in thin, weakly banded collagen fibrils also containing collagens II and XI. PMID: 12782140
    8. interacts with fibrillin-1 and with fibronectin indicating multiple molecular interactions in which this ubiquitously expressed and versatile fibril-associated collagens with interrupted triple helices-collagen can participate PMID: 15165854
    9. These results demonstrate de-novo expression of collagen XVI in glioblastomas as part of the tumor specific remodeling of the ECM. PMID: 18804107

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibril-associated collagens with interrupted helices (FACIT) family
  • 组织特异性：
    In papillary dermis, is a component of specialized fibrillin-1-containing microfibrils, whereas in territorial cartilage matrix, it is localized to a discrete population of thin, weakly banded collagen fibrils in association with other collagens (at prote
  • 数据库链接：

    HGNC: 2193

    OMIM: 120326

    KEGG: hsa:1307

    STRING: 9606.ENSP00000362776

    UniGene: Hs.368921