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COG7 Antibody

  • 货号：
    CSB-PA005711ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA005711ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA005711ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) COG7 Polyclonal antibody
  • Uniprot No.：
    P83436
  • 基因名：
    COG7
  • 别名：
    CDG2E antibody; COG complex subunit 7 antibody; cog7 antibody; COG7_HUMAN antibody; Component of oligomeric Golgi complex 7 antibody; Conserved oligomeric Golgi complex component 7 antibody; Conserved oligomeric Golgi complex subunit 7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Conserved oligomeric Golgi complex subunit 7 protein (511-770AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for normal Golgi function.
  • 基因功能参考文献：
    1. Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex. PMID: 25331899
    2. COG5- and COG7 subunits play distinctive roles in controlling Golgi structure and function PMID: 16051600
    3. Retrograde transport of multiple Golgi proteins to the ER in COG-7-deficient patient fibroblasts via brefeldin A-induced tubules was significantly slower than occurs in normal fibroblasts. PMID: 16510524
    4. A homozygous, intronic splice site mutation (c.169+4A>C) of the COG7 gene was identified in 3 patients with Congenital Disorder of Glycosylation type IIe. PMID: 17356545
    5. A new mutation in COG7 extends the spectrum of COG subunit deficiencies. PMID: 19577670

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  • 相关疾病：
    Congenital disorder of glycosylation 2E (CDG2E)
  • 亚细胞定位：
    Golgi apparatus membrane; Peripheral membrane protein.
  • 蛋白家族：
    COG7 family
  • 数据库链接：

    HGNC: 18622

    OMIM: 606978

    KEGG: hsa:91949

    STRING: 9606.ENSP00000305442

    UniGene: Hs.185807