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COG6 Antibody

  • 货号：
    CSB-PA23419A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA23419A0Rb diluted at 1:500 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) COG6 Polyclonal antibody
  • Uniprot No.：
    Q9Y2V7
  • 基因名：
    COG6
  • 别名：
    CDG2L antibody; COD2 antibody; COG complex subunit 6 antibody; COG6 antibody; COG6_HUMAN antibody; Complexed with Dor1p 2 antibody; Component of oligomeric Golgi complex 6 antibody; Conserved oligomeric Golgi complex component 6 antibody; Conserved oligomeric Golgi complex protein 6 antibody; Conserved oligomeric Golgi complex subunit 6 antibody; KIAA1134 antibody; SHNS antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Conserved oligomeric Golgi complex subunit 6 protein (556-653AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，COG6 Antibody (CSB-PA23419A0Rb)，的标记方式是Non-conjugated。对于COG6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA23419B0Rb COG6 Antibody, HRP conjugated ELISA
    FITC CSB-PA23419C0Rb COG6 Antibody, FITC conjugated
    Biotin CSB-PA23419D0Rb COG6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for normal Golgi function.
  • 基因功能参考文献：
    1. COG6 is a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus. PMID: 27193031
    2. study presents 7 additional patients with 4 novel COG6 mutations; genotype-phenotype correlation can be discerned ranging from deep intronic mutations found in Shaheen syndrome as the mildest form to loss-of-function mutations leading to early lethal congenital disorders of glycosylation phenotypes PMID: 26260076
    3. The aim of this study was to investigate whether the HCP5, TNIP1, TNFAIP3, SPATA2 and COG6 genes were genetic risk factors for psoriasis in Chinese population. PMID: 25264125
    4. Our findings implicate COG6 rs9548934C-->T genotypes and circulating miRNA-1 phenotype in modulating the occurrence and major adverse cardiovascular events of coronary artery disease. PMID: 25197382
    5. Targeted silencing of components of lobe B of the COG complex, namely COG5, COG6, COG7 and COG8, inhibited HIV-1 replication PMID: 25179963
    6. data implicate COG6 in the pathogenesis of a novel hypohidrotic disorder in humans that is distinct from congenital disorders of glycosylation. PMID: 23606727
    7. COG6 interaction with SNARE proteins via universal SNARE-binding motif of COG6 is important for Golgi complex intergrity. PMID: 23057818
    8. COG6 rs9548934C-->T polymorphism is associated with lower risk of premature coronary artery disease, especially in female subjects and subjects with lower serum lipid levels. PMID: 22883088
    9. COG directly and positively regulates endosome-to-TGN retrograde transport by specific and direct interaction with the t-SNARE Stx6 via its Cog6 subunit. PMID: 21807881
    10. This paper reports a new congenital disorder caused by mutations in the human COG8 gene and describes the affect this mutation has on the other COG components. PMID: 17331980

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  • 相关疾病：
    Congenital disorder of glycosylation 2L (CDG2L); Shaheen syndrome (SHNS)
  • 亚细胞定位：
    Golgi apparatus membrane; Peripheral membrane protein.
  • 蛋白家族：
    COG6 family
  • 数据库链接：

    HGNC: 18621

    OMIM: 606977

    KEGG: hsa:57511

    STRING: 9606.ENSP00000397441

    UniGene: Hs.507805