Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. CNTNAP1 Antibody

CNTNAP1 Antibody

  • 货号：
    CSB-PA005692LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA005692LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA005692LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CNTNAP1 Polyclonal antibody
  • Uniprot No.：
    P78357
  • 基因名：
    CNTNAP1
  • 别名：
    Caspr antibody; Caspr1 antibody; CNTNAP antibody; Cntnap1 antibody; CNTP1_HUMAN antibody; Contactin associated protein 1 antibody; Contactin-associated protein 1 antibody; MHDNIV antibody; NCP1 antibody; Neurexin 4 antibody; Neurexin IV antibody; Neurexin-4 antibody; Nrxn4 antibody; p190 antibody; Paranodin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Contactin-associated protein 1 protein (26-356AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CNTNAP1 Antibody (CSB-PA005692LA01HU)，的标记方式是Non-conjugated。对于CNTNAP1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA005692LB01HU CNTNAP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA005692LC01HU CNTNAP1 Antibody, FITC conjugated
    Biotin CSB-PA005692LD01HU CNTNAP1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells.
  • 基因功能参考文献：
    1. E. coli exploits Caspr1 as a host receptor for penetration of the blood-brain barrier, resulting in meningitis PMID: 29895952
    2. In two brothers with severe congenital hypotonia and foot deformities, we identified compound heterozygous variants in CNTNAP1, reporting the first causative missense variant, p.(Cys323Arg). Motor nerve conductions were markedly decreased. PMID: 27782105
    3. CNTNAP1 mutations were found to induce characteristic ultrastructural lesions of the paranodal region. PMID: 27818385
    4. report a consanguineous Arab family from Qatar with three children having an early lethal form of arthrogryposis multiplex congenita and a novel frameshift mutation in CNTNAP1 PMID: 28254648
    5. Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects PMID: 24319099

    显示更多

    收起更多

  • 相关疾病：
    Lethal congenital contracture syndrome 7 (LCCS7)
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Cell junction, paranodal septate junction.
  • 蛋白家族：
    Neurexin family
  • 组织特异性：
    Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.
  • 数据库链接：

    HGNC: 8011

    OMIM: 602346

    KEGG: hsa:8506

    STRING: 9606.ENSP00000264638

    UniGene: Hs.408730