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CNTN2 Antibody

  • 中文名称：
    CNTN2兔多克隆抗体
  • 货号：
    CSB-PA438362
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from NIH-3T3 cells, using CNTN2 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CNTN2 Polyclonal antibody
  • Uniprot No.：
    Q02246
  • 基因名：
    CNTN2
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human CNTN2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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靶点详情

  • 功能：
    In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.
  • 基因功能参考文献：
    1. the selective distribution of Caspr2 and TAG-1 may be regulated, allowing them to modulate the strategic function of the Kv1 complex along axons PMID: 28533267
    2. the ectodomains of CNTNAP2 and contactin 2 (CNTN2) bind directly and specifically, with low nanomolar affinity. PMID: 27621318
    3. RACK1 interacts with CNTN2, and the effects of RACK1 on glioma cell growth and differentiation are mediated by CNTN2. PMID: 26718491
    4. Our results clearly demonstrate that mouse and human contactin-2 are physiological substrates for BACE1 PMID: 24405708
    5. A single nucleotide deletion in exon 6 of CNTN2 results in a frameshift mutation, segregating in a recessive manner in a consanguineous Egyptian family with epilepsy. PMID: 23518707
    6. The single-nucleotide polymorphism (SNP) rs2275697 in the TAG-) gene was not associated with treatment responsiveness, treatment dependence, disability, or mortality in chronic inflammatory demyelinating polyneuropathy PMID: 22462668
    7. allelic variation in TAG-1 does not play a major role in determining multifocal motor neuropathy susceptibility. PMID: 22003931
    8. single nucleotide polymorphisms in TAG-1 are related to the IVIg responsiveness of Chronic inflammatory demyelinating polyneuropathy patients. PMID: 21696500
    9. The domains responsible for the neurite outgrowth promoting activity of TAG-1 have been investigated as well as its interactions with other cell adhesion molecules. PMID: 12139915
    10. TAG-1 homophilic interaction is based on dimer formation rather than formation of a molecular zipper as proposed for the chicken ortholog. PMID: 17766378
    11. Contactin-2 is expressed by various neuronal populations and sequestered in the juxtaparanodal domain of myelinated axons both at the axonal and myelin sides; is an autoantigen targeted by T cells and autoantibodies in MS. PMID: 19416878
    12. immune response to CNTN2 and possible involvement in multiple sclerosis and EAE [REVIEW] PMID: 19451620

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  • 相关疾病：
    Epilepsy, familial adult myoclonic, 5 (FAME5)
  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Note=Attached to the neuronal membrane by a GPI-anchor and is also released from neurons.
  • 蛋白家族：
    Immunoglobulin superfamily, Contactin family
  • 数据库链接：

    HGNC: 2172

    OMIM: 190197

    KEGG: hsa:6900

    STRING: 9606.ENSP00000330633

    UniGene: Hs.519220