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CNTFR Antibody

  • 货号：
    CSB-PA276708
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from Rat brain tissue and Hela cells using CNTFRa Antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CNTFR Polyclonal antibody
  • Uniprot No.：
    P26992
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around aa.119~123(N-T-Y-P-K) derived from Human CNTFRa
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and IL27RA/WSX1.
  • 基因功能参考文献：
    1. The family-based study showed no association between the CNTFR rs7036351, NET rs3785143 polymorphisms, and attention-deficit hyperactivity disorder. PMID: 24565995
    2. gene expression and surface expression in NK92 cells of ciliary neurotrophic factor alpha (CNTFR-alpha) and glycoprotein (gp)130 in natural killer (NK) cells, in the context of malaria, were investigated. PMID: 23398366
    3. Data indicate that CNTFRalpha plays a role in the formation or maintenance of tumor-initiating cells in gliomas, is a marker that correlates with histological grade, may underlie treatment resistance in some cases, and is a potential therapeutic target. PMID: 23061382
    4. expression of neurotrophin receptors Pan-Trk, p75 neurotrophin receptor (p75(NTR) and ciliary neurotrophic factor receptor-alpha in ulveal melanoma does not show a role in growth. PMID: 22343487
    5. Data show that variants in CNTFR were significantly associated with a lower age at onset of the eating disorders. PMID: 20219210
    6. interactions of CNTFR with LIFR and gp130 in vitro PMID: 12707266
    7. C174T polymorphism in exon 9 of CNTFR is significantly associated with fat-free mass in men and women, with concomitant differences in muscular strength. PMID: 12807897
    8. Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha. PMID: 16782820
    9. In liver CNTFRalpha serves as a key modulator in regulating PI3K and AMP-activated protein kinase dynamically under CNTF stimulation, resulting in the increase of glucose uptake and translocation of glucose transporter 4. PMID: 18307269
    10. These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR/WSX-1/gp130. PMID: 19386761

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Type I cytokine receptor family, Type 3 subfamily
  • 组织特异性：
    Nervous system and skeletal muscle.
  • 数据库链接：

    HGNC: 2170

    OMIM: 118946

    KEGG: hsa:1271

    STRING: 9606.ENSP00000242338

    UniGene: Hs.129966