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CNPY2 Antibody

  • 货号：
    CSB-PA05034A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: CNPY2 antibody at 2µg/ml + 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 21, 10 kDa
      Observed band size: 47 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA05034A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CNPY2 Polyclonal antibody
  • Uniprot No.：
    Q9Y2B0
  • 基因名：
    CNPY2
  • 别名：
    Canopy 2 homolog (zebrafish) antibody; Cnpy2 antibody; CNPY2_HUMAN antibody; MIR-interacting saposin-like protein antibody; MSAP antibody; Protein canopy homolog 2 antibody; Putative secreted protein ZSIG9 antibody; TMEM4 antibody; Transmembrane protein 4 antibody; UNQ1943/PRO4426 antibody; ZSIG9 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein canopy homolog 2 protein (22-182AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CNPY2 Antibody (CSB-PA05034A0Rb)，的标记方式是Non-conjugated。对于CNPY2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA05034B0Rb CNPY2 Antibody, HRP conjugated ELISA
    FITC CSB-PA05034C0Rb CNPY2 Antibody, FITC conjugated
    Biotin CSB-PA05034D0Rb CNPY2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
  • 基因功能参考文献：
    1. CNPY2 knockout resulted in the significant suppression of MHCC97H cell proliferation, tumor growth, and hemorrhage. PMID: 30415246
    2. Overexpression of CNPY2 can activate the AKT/GSK3beta pathway, which leads to the inactivation of GSK-3beta. The inactivation of GSK-3beta increases the level of Snail, and then decreases the expression of E-cadherin to promote EMT. PMID: 29569784
    3. CNPY2 can serve as a therapeutic target to promote the effect of chemotherapy in non-small cell lung cancer. PMID: 29864955
    4. CNPY2 isoform2 represents as a novel and valuable prognostic indicator for colorectal cancer patients. PMID: 29135454
    5. These findings suggested that CNPY2 promoted cancer cell growth in renal cell carcinoma cells through regulating TP53 gene expression. PMID: 28235487
    6. CNPY2 may play a critical role in colorectal cancer development by enhancing cell proliferation, migration, and angiogenesis and by inhibiting apoptosis through negative regulation of the p53 pathway PMID: 26835537
    7. CNPY2 is a HIF-1alpha-regulated, secreted angiogenic growth factor that promotes smooth muscle cell migration, proliferation, and tissue revascularization. PMID: 25589425
    8. Our results are consistent with an important role of FGF21 and Cnpy2/Msap in the regulation of LDLRs in cultured cells. PMID: 22378787
    9. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain in fetal and adult brain. PMID: 12826659

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  • 亚细胞定位：
    Endoplasmic reticulum.
  • 蛋白家族：
    Canopy family
  • 组织特异性：
    Expressed in different tissues. Highest levels are detected in adult placenta, liver and pancreas.
  • 数据库链接：

    HGNC: 13529

    OMIM: 605861

    KEGG: hsa:10330

    STRING: 9606.ENSP00000273308

    UniGene: Hs.8752