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CNP Antibody

  • 货号：
    CSB-PA468752
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of MCF7 cells using CNPase Polyclonal Antibody
    • Western Blot analysis of various cells using CNPase Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P09543
  • 基因名：
    CNP
  • 别名：
    2'' antibody; 2'3' cyclic nucleotide 3' phosphodiesterase antibody; 3''-cyclic-nucleotide 3''-phosphodiesterase antibody; CN37_HUMAN antibody; CNP 1 antibody; CNP antibody; CNP1 antibody; CNPase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CNPase.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
  • 基因功能参考文献：
    1. This study showed that the expression of CNPase protein was significantly decreased but increase expression mrna in ventral prefrontal white matter in major depressive disorder. PMID: 25930075
    2. kidneys express 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), and renal CNPase mediates in part the renal 2',3'-cAMP-adenosine pathway PMID: 24808540
    3. 2',3'-cyclic nucleotide 3'-phosphodiesterases inhibit hepatitis B virus replication. PMID: 24260477
    4. No Alzheimer disease-associated differences in CNP and DPYSL2 promoter DNA methylation were observed. PMID: 22954668
    5. CNP binds to the structural protein Gag and blocks HIV-1 particle assembly after Gag and viral RNA have associated with the plasma membrane. PMID: 23084924
    6. Bipolar I disorder and schizophrenia ahare a number of common genetic risk loci and susceptibility genes including the genes coding for 2',3'-cyclic nucleotide 3' phosphodiesterase enzyme. PMID: 23032943
    7. Differential CNP expression correlated with mouse model survival, and CNP immunoassay of a large GBM tissue microarray also showed significant differential patient survival PMID: 22589395
    8. The characteristic features in both humans and mice with their partial CNP 'loss-of-function' genotype are best described as 'catatonia-depression' syndrome. PMID: 22473874
    9. verified the molecular interaction of Nogo-A with 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP), which could act as a conformational stabilizer for the intrinsically unstructured large segment of Amino-Nogo PMID: 19508346
    10. crystal structure of 2',3'-cyclic nucleotide 3'-phosphohydrolase PMID: 15502338
    11. crystal structure of the catalytic fragment PMID: 15713463
    12. reduced CNP expression in the schizophrenic brain is relevant to disease etiology and therefore provide support for the general hypothesis that altered oligodendrocyte function is an etiological factor in schizophrenia. PMID: 16389193
    13. The crystal structure of the catalytic fragment of human CNP (hCNP-CF) at 1.3 A resolution, is determined. PMID: 17150526
    14. study did not find an association between genetic variations in the CNP gene and schizophrenia in the Han Chinese population PMID: 17306456
    15. MOBP and CNP protein in the white matter was not altered. PMID: 17964117
    16. The effect of rs2070106 genotype on the CNP expression was transcript specific, and that the genotype was not associated with the expression of other oligodendrocyte-related genes. PMID: 18289148
    17. This finding provides support for potential association of the CNP gene but not the MAG gene in schizophrenia in a Caucasian population. PMID: 18496213
    18. Almost all multiple sclerosis patients had cerebrospinal fluid IgG directed to isoforms of one of the oligodendroglial molecules, transketolase, 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I, collapsin response mediator protein 2, and tubulin beta4. PMID: 18676363
    19. The results suggest that the CNP gene may not be involved in the etiology and pathology of schizophrenia in the Chinese population PMID: 19348671
    20. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia PMID: 19165527
    21. The larger CNP isoform, CNP2, contains an N-terminal mitochondrial targeting signal and is localized either in the cytoplasm or mitochondria. Mitochondrial localization is regulated by phosphorylation of the targeting signal by PKC. PMID: 16343930
    22. CNP interacts with tubulin and promotes microtubule assembly for process outgrowth in oligodendrocytes. PMID: 16103231

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  • 亚细胞定位：
    Membrane; Lipid-anchor. Melanosome. Note=Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • 蛋白家族：
    2H phosphoesterase superfamily, CNPase family
  • 数据库链接：

    HGNC: 2158

    OMIM: 123830

    KEGG: hsa:1267

    STRING: 9606.ENSP00000377470

    UniGene: Hs.273621