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  4. CNOT8 Antibody

CNOT8 Antibody

  • 货号：
    CSB-PA005673GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UFF9
  • 基因名：
    CNOT8
  • 别名：
    CAF 1 antibody; CAF 2 antibody; CAF1 antibody; CAF1 like protein antibody; CAF1-like protein antibody; CAF2 antibody; CALIF antibody; CALIFp antibody; CCR4 associated factor 8 antibody; CCR4 NOT transcription complex subunit 8 antibody; CCR4-associated factor 8 antibody; CCR4-NOT transcription complex subunit 8 antibody; CNOT 8 antibody; Cnot8 antibody; CNOT8_HUMAN antibody; hCAF1 antibody; PGK promoter directed over production antibody; POP 2 antibody; POP2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CNOT8
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
  • 基因功能参考文献：
    1. These results indicate that Caf1 and Ccr4 cooperate in mRNA deadenylation and suggest that the enzyme activities of Caf1 and Ccr4 are regulated via allosteric interactions within the nuclease module. PMID: 25944446
    2. The loss of CAF-1 p48 subunit causes a strong defect in packaging DNA into nucleosomes. PMID: 24036545
    3. show that SMG7 binds directly to POP2, a catalytic subunit of the CCR4-NOT deadenylase complex, and elicits deadenylation-dependent decapping and 5'-to-3' decay of NMD targets PMID: 24115769
    4. The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. PMID: 23236473
    5. The NOT1 MIF4G domain binds CAF1 through a pre-formed interface and leaves the CAF1 catalytic site fully accessible to RNA substrates. PMID: 22977175
    6. N-terminus played a role in modulating hCaf1 activity, stability and aggregation PMID: 22683897
    7. Together, these results indicate that Tob mediates the recruitment of Caf1 to the target of CPEB3 and elicits deadenylation and decay of the mRNA. PMID: 21336257
    8. Tob interactions with Caf1 and a C-terminal domain of PABPC1 PMID: 20595394
    9. CCR4-NOT is the deadenylase that removes poly(A) from messages destabilized by miRNAs in human cells. PMID: 20065043
    10. Cellular POP2 protein binds to central adaptor protein ASC and pathogen recognition receptor PAN1, blocking formation of cryopyrin and PAN1-containing inflammasomes, activation of caspase-1, and subsequent processing of bioactive interleukin-1 beta. PMID: 17178784
    11. Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT8 binds CNOT6 in yeast two-hybrid assays. PMID: 19558367
    12. Data show that efficient cell proliferation requires both CNOT7 and CNOT8, although combined knockdown of both subunits further reduces cell proliferation indicating partial redundancy between these proteins. PMID: 19605561

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CAF1 family
  • 数据库链接：

    HGNC: 9207

    OMIM: 603731

    KEGG: hsa:9337

    STRING: 9606.ENSP00000285896

    UniGene: Hs.26703