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CNN2 Antibody

  • 货号：
    CSB-PA860764LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, Mouse liver tissue, Mouse lung tissue, Mouse kidney tissue, Mouse brain tissue, Mouse skeletal muscle tissue
      All lanes: CNN2 antibody at 2.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 34, 30 kDa
      Observed band size: 34 kDa
    • Immunofluorescent analysis of HepG2 cells using CSB-PA860764LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CNN2 Polyclonal antibody
  • Uniprot No.：
    Q99439
  • 基因名：
    CNN2
  • 别名：
    Calponin 2 antibody; Calponin H2 antibody; Calponin H2, smooth muscle antibody; Calponin-2 antibody; Cnn2 antibody; CNN2_HUMAN antibody; Neutral calponin antibody; smooth muscle antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Calponin-2 protein (2-309AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CNN2 Antibody (CSB-PA860764LA01HU)，的标记方式是Non-conjugated。对于CNN2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA860764LB01HU CNN2 Antibody, HRP conjugated ELISA
    FITC CSB-PA860764LC01HU CNN2 Antibody, FITC conjugated
    Biotin CSB-PA860764LD01HU CNN2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
  • 基因功能参考文献：
    1. Study in human hepatocellular carcinoma cell line and xenograft mouse model shows that CNN2 plays an important role in tumor growth and metastasis, possibly through MEK1/2-ERK1/2 signaling pathway. PMID: 29333089
    2. our results demonstrated that knockdown of endogenous CNN2 in AGS cells could significantly activate cell apoptosis pathway and therefore suppress cell growth in vitro. The deletion of CNN2 might be a potential therapeutic approach to inhibit aggressive growth of gastric cancer. PMID: 28714360
    3. High Calponin-h2 serum levels are associated with breast cancer. PMID: 25099617
    4. h2-Calponin gene expression is further affected by the treatment of cells with Notch inhibitor and activator, suggesting an upstream signaling mechanism. PMID: 24285540
  • 蛋白家族：
    Calponin family
  • 组织特异性：
    Heart and smooth muscle.
  • 数据库链接：

    HGNC: 2156

    OMIM: 602373

    KEGG: hsa:1265

    STRING: 9606.ENSP00000263097

    UniGene: Hs.651512