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CNGA2 Antibody

  • 货号：
    CSB-PA001733
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using CNG-2 Polyclonal Antibody
    • Western Blot analysis of various cells using CNG-2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q16280
  • 基因名：
  • 别名：
    CNCA antibody; CNCA1 antibody; CNCG2 antibody; CNG 2 antibody; CNG channel alpha 2 antibody; CNG channel alpha-2 antibody; CNG-2 antibody; CNG2 antibody; CNGA 2 antibody; Cnga2 antibody; CNGA2_HUMAN antibody; Cyclic nucleotide gated cation channel 2 antibody; Cyclic nucleotide gated channel alpha 2 antibody; Cyclic nucleotide gated olfactory channel antibody; Cyclic nucleotide-gated cation channel 2 antibody; Cyclic nucleotide-gated channel alpha-2 antibody; Cyclic nucleotide-gated olfactory channel antibody; FLJ46312 antibody; OCNC1 antibody; OCNCa antibody; OCNCALPHA antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CNG-2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.
  • 基因功能参考文献：
    1. The studies findings provides strong support for role of CNGA2 gene with pathogenicity of isolated congenital anosmia in humans. Together, these results indicate that mutations in key olfactory signaling pathway genes are responsible for human disease. PMID: 28572688
    2. Identification of a novel X-linked stop mutation in CNGA2 (c.634C>T, p.R212*) in two brothers with isolated congenital anosmia. PMID: 25156905
    3. The results showed that it is predominantly the charge of the E342 residue in the P-loop, rather than the pore helix dipoles, which controls the cation-anion selectivity of the CNGA2 channel. PMID: 16533895
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGA2 subfamily
  • 数据库链接：

    HGNC: 2149

    OMIM: 300338

    KEGG: hsa:1260

    STRING: 9606.ENSP00000328478

    UniGene: Hs.447360