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CMTM4 Antibody

  • 中文名称：
    CMTM4兔多克隆抗体
  • 货号：
    CSB-PA007375
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HELA cells using CMTM4 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q8IZR5
  • 基因名：
    CMTM4
  • 别名：
    CMTM4; CKLFSF4; CKLF-like MARVEL transmembrane domain-containing protein 4; Chemokine-like factor superfamily member 4
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CMTM4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.
  • 基因功能参考文献：
    1. CMTM4 is downregulated and exhibits tumour-suppressor activities in clear cell renal cell carcinoma, and could be exploited as a target for clear cell renal cell carcinoma treatment. PMID: 26474560
    2. Data show that CMTM4 might be an important gene involved in cell growth and cell cycle regulation. PMID: 20213316
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Chemokine-like factor family
  • 组织特异性：
    Highly expressed in testis and prostate.
  • 数据库链接：

    HGNC: 19175

    OMIM: 607887

    KEGG: hsa:146223

    STRING: 9606.ENSP00000333833

    UniGene: Hs.643961