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CMPK1 Antibody

  • 货号：
    CSB-PA004391
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HeLa cells using UMP-CMP Kinase Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P30085
  • 基因名：
    CMPK1
  • 别名：
    CMK antibody; CMPK 1 antibody; CMPK antibody; cmpk1 antibody; Cytidine monophosphate (UMP CMP) kinase 1 cytosolic antibody; Cytidine monophosphate kinase antibody; Cytidine monophosphate UMP CMP kinase 1 cytosolic antibody; Cytidylate kinase antibody; dCMP kinase antibody; Deoxycytidylate kinase antibody; EC 2.7.4.14 antibody; KCY antibody; KCY_HUMAN antibody; Monophosphatase kinase antibody; OTTHUMP00000009565 antibody; RP11 511I2.1 antibody; UCK antibody; UMK antibody; UMP CMP antibody; UMP CMP kinase antibody; UMP-CMP kinase antibody; UMP/CMP kinase antibody; UMP/CMPK antibody; UMPK antibody; Uridine monophosphate kinase antibody; Uridine monophosphate/cytidine monophosphate kinase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human UMP-CMP Kinase.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
  • 基因功能参考文献：
    1. Nuclear CMPK1 expression is indicative of poor prognosis in the triple negative breast cancer patients. PMID: 27558661
    2. TGF-b1 inhibited the expression of CMPK, which was blocked in the presence of a TGF-b type I receptor, SB431542, and was abolished by the inhibitor of miR-130b-3p, indicating that CMPK is regulated by the TGF-b signalling pathway through the upregulation of miR-130b-3p. PMID: 28414100
    3. The role of CMP/UMP kinase (CMPK), an enzyme catalyzes cytidine diphosphate formation, in DNA repair, was investigated. PMID: 25659034
    4. CMPK1 and RBP3 are associated with corneal curvature in Asian populations. PMID: 24963161
    5. In particular, polymorphisms of the CMPK1 gene seem to provide important prognostic information PMID: 22838950
    6. Single-nucleotide polymorphisms in CMPK1 gene is associated with treatment response in non-small cell lung cancer. PMID: 21642870
    7. UMP/CMP kinase (EC 2.7.4.14) is not critical for the phosphorylation of CMP, dCMP and maintenance of natural nucleotide pools in cells PMID: 21559290
    8. thymidylate synthase/ribonucleotide reductase gene silencing and deoxycytidine kinase::uridine monophosphate kinase fusion gene gene overexpression markedly improved gemcitabine's therapeutic activity PMID: 19568409
    9. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. PMID: 11912132
    10. UMP/CMP kinase reveals the conformational changes that occur upon substrate binding PMID: 15163660
    11. Models for the phosphorylation action and substrate specificity of human UMP/CMP kinase. PMID: 15550676
    12. Several uracil vinylphosphonate derivatives had affinities for human UMP-CMP kinase similar to those of dUMP PMID: 17608725

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Adenylate kinase family, UMP-CMP kinase subfamily
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 18170

    OMIM: 191710

    KEGG: hsa:51727

    STRING: 9606.ENSP00000360939

    UniGene: Hs.731647