Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. CLYBL Antibody

CLYBL Antibody

  • 货号：
    CSB-PA850772LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, Jurkat whole cell lysate, THP-1 whole cell lysate, HepG2 whole cell lysate, NIH/3T3 whole cell lysate
      All lanes: CLYBL antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 38, 34 KDa
      Observed band size: 38 KDa
      Exposure time：5min
    • IHC image of CSB-PA850772LA01HU diluted at 1:50 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at 37℃ Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CLYBL Polyclonal antibody
  • Uniprot No.：
    Q8N0X4
  • 基因名：
    CLYBL
  • 别名：
    CLYBL antibody; CLB antibody; Citramalyl-CoA lyase antibody; mitochondrial antibody; EC 4.1.3.25; antibody; 3S)-malyl-CoA thioesterase antibody; EC 3.1.2.30 antibody; Beta-methylmalate synthase antibody; EC 2.3.3.- antibody; Citrate lyase subunit beta-like protein antibody; Citrate lyase beta-like antibody; Malate synthase antibody; EC 2.3.3.9 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Citrate lyase subunit beta-like protein, mitochondrial protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CLYBL Antibody (CSB-PA850772LA01HU)，的标记方式是Non-conjugated。对于CLYBL Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA850772LB01HU CLYBL Antibody, HRP conjugated ELISA
    FITC CSB-PA850772LC01HU CLYBL Antibody, FITC conjugated
    Biotin CSB-PA850772LD01HU CLYBL Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro.
  • 基因功能参考文献：
    1. Study reports that CLYBL loss leads to a cell-autonomous defect in the mitochondrial B12 metabolism and that itaconyl-CoA is a cofactor-inactivating, substrate-analog inhibitor of the mitochondrial B12-dependent methylmalonyl-CoA mutase PMID: 29056341
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    HpcH/HpaI aldolase family, Citrate lyase beta subunit-like subfamily
  • 数据库链接：

    HGNC: 18355

    OMIM: 609686

    KEGG: hsa:171425

    STRING: 9606.ENSP00000342991

    UniGene: Hs.655642