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CLOCK Antibody

  • 货号:
    CSB-PA005574EA01HU
  • 规格:
    ¥440
  • 促销:
    小规格抗体限时一口价
  • 图片:
    • Western Blot
      Positive WB detected in: Hela whole cell lysate
      All lanes: CLOCK antibody at 3.5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 96 kDa
      Observed band size: 96 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA005574EA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA005574EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

产品详情

  • 产品名称:
    Rabbit anti-Homo sapiens (Human) CLOCK Polyclonal antibody
  • Uniprot No.:
    O15516
  • 基因名:
    CLOCK
  • 别名:
    bHLHe8 antibody; Circadian locomoter output cycles kaput protein antibody; Circadian locomoter output cycles protein kaput antibody; Circadian Locomotor Output Cycles Kaput antibody; Circadium Locomotor Output Cycles Kaput antibody; Class E basic helix-loop-helix protein 8 antibody; CLOCK antibody; Clock circadian regulator antibody; Clock homolog antibody; Clock protein antibody; CLOCK_HUMAN antibody; hCLOCK antibody; KIAA0334 antibody
  • 宿主:
    Rabbit
  • 反应种属:
    Human
  • 免疫原:
    Recombinant Human Circadian locomoter output cycles protein kaput protein (577-846AA)
  • 免疫原种属:
    Homo sapiens (Human)
  • 标记方式:
    Non-conjugated

    本页面中的产品,CLOCK Antibody (CSB-PA005574EA01HU),的标记方式是Non-conjugated。对于CLOCK Antibody,我们还提供其他标记。见下表:

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA005574EB01HU CLOCK Antibody, HRP conjugated ELISA
    FITC CSB-PA005574EC01HU CLOCK Antibody, FITC conjugated
    Biotin CSB-PA005574ED01HU CLOCK Antibody, Biotin conjugated ELISA
  • 克隆类型:
    Polyclonal
  • 抗体亚型:
    IgG
  • 纯化方式:
    >95%, Protein G purified
  • 浓度:
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式:
    Liquid
  • 应用范围:
    ELISA, WB, IHC, IF
  • 推荐稀释比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 储存条件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能:
    Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. ...显示更多
  • 基因功能参考文献:
    1. As a novel CLOCK-dependent diurnal gene, TIMP3 inhibits the expression of inflammatory cytokines that are up-regulated by UV irradiation in human keratinocytes. PMID: 29180440
    2. the CLOCK gene polymorphism is one of factors determining elastic properties of vascular wall PMID: 28290876
    3. Rhythmic luciferase activity from clock gene luciferase reporter cells lines was used to test the effect of p38 MAPK inhibition on clock properties as determined using the damped sine fit and Levenberg-Marquardt algorithm.Glioma treatment with p38 MAPK inhibitors may be more effective and less toxic if administered at the appropriate time of the day. PMID: 29316898
    4. data suggest that SNP variability in the CLOCK gene for rs6850524 and rs11932595 is associated with idiopathic recurrent spontaneous abortion in pregnancies from Slovenia and Serbia PMID: 29768442
    5. Results indicated that inhibiting the circadian gene Clock expression can reverse the cisplatin resistance of ovarian cancer SKOV3/DDP cell lines by affecting the protein expression of drug resistance genes during which autophagy plays an important role. PMID: 28514207
    6. Low expression of CLOCK protein is associated with kidney tumor. PMID: 29271044
    7. Association between HCRTR2, ADH4,CLOCK gene polymorphisms and cluster headache was not significant in the present study. PMID: 29318394
    8. No association between 3111T/C Clock gene polymorphism and complaints of patients with insomnia was detected. PMID: 28853078
    9. Study found three gene variants (CLOCK-rs4864548, PEMT-rs936108, and GHRELIN-rs696217) that exhibited uncorrected gene-by-sleep duration interactions in relation to BMI z-scores in a cohort of New Zealand European children. However, no interactions were identified in percentage body fat differences. Notably, these interactions are evident without detectable effects on sleep duration. PMID: 28899534
    10. These findings suggest that upregulation of the circadian gene hClock plays an important role in metastasis of colorectal cancer. PMID: 28498393
    11. results of this study suggest that genetic variability in the ARNTL and CLOCK genes might be associated with risk for multiple sclerosis PMID: 29324865
    12. Evening chronotype is associated with higher obesity in severely obese subjects and with lower weight loss effectiveness after bariatric surgery. In addition, circadian preferences interact with CLOCK 3111T/C for obesity. The circadian and genetic assessment could provide tailored weight loss recommendations in subjects who underwent bariatric surgery. PMID: 27339606
    13. CLOCK regulates the expression of genes involved in neuronal migration, and a functional assay showed that CLOCK knockdown increased neuronal migratory distance. PMID: 29196536
    14. Our findings suggest that CLOCK and CRY1 polymorphisms might be involved in individual susceptibility to abdominal obesity in Chinese Han population. PMID: 26923944
    15. Our results suggest that the circadian gene human Clock may play an important role in carcinogenesis by inhibiting apoptotic cell death via attenuating proapoptotic signaling PMID: 25976934
    16. ASS1 acetylation by CLOCK exhibits circadian oscillation in human cells and mouse liver, possibly caused by rhythmic interaction between CLOCK and ASS1, leading to the circadian regulation of ASS1 and ureagenesis. PMID: 28985504
    17. CLOCK SNP rs2070062 is associated with shorter sleep duration. PMID: 28645331
    18. This study showed that Lack of Association between Genetic Polymorphism of clock gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population This study showed that Lack of Association between Genetic Polymorphism of PER2 gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population PMID: 27335043
    19. CLOCK gene expression mean was significantly higher in morning than in evening during Shabaan PMID: 28384165
    20. found that overexpression of both Clock and Bmal1 suppressed cell growth PMID: 26370682
    21. Clock circadian regulator (CLOCK) gene single nucleotide polymorphism rs1801260 minor allele C showed a significantly higher association with the prevalence of diabetes in the Japanese population independent of body mass index (BMI). PMID: 26374515
    22. a novel mechanism of action of CLOCK in human umbilical vein endothelial cells, is reported. PMID: 28058089
    23. Low Clock gene expression is associated with colorectal liver metastases. PMID: 27492458
    24. The possession of CLOCK rs3749474 may influence the effect of reducing the percentage intake of dietary fat on obesity-associated variables and carrying this SNP might benefit more than others from weight loss treatment involving dietary fat restriction. PMID: 26690565
    25. CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects. Suggest diet-gene interaction. PMID: 26739996
    26. Clock gene variants associated with obesity and sleep duration. [review] PMID: 26553137
    27. CLOCK rs1801260 modulated the relationship between early stress, adult history of attempted suicide and current suicide ideation PMID: 26204460
    28. The CLOCK 3111T > C polymorphism could be an independent risk factor for irregular menstrual cycles, irrespective of psychological distress and endocrine or metabolic conditions in Korean adolescents. PMID: 26453284
    29. Findings indicate that CLOCK protein plays an important role in fertility and its knockdown leads to reduction in reproduction and increased miscarriage risk. PMID: 26390085
    30. when overexpressed, c-MYC is able to repress Per1 transactivation by BMAL1/CLOCK via targeting selective E-box sequences. Importantly, upon serum stimulation, MYC was detected in BMAL1 protein complexes PMID: 26850841
    31. Variants of the CLOCK gene are associated with idiopathic male infertility and therefore may be applied as a risk factor of male infertility. PMID: 26181468
    32. CLOCK, ARNTL, and NPAS2 gene polymorphisms may have a role in seasonal variations in mood and behavior PMID: 26134245
    33. minor polymorphisms of CLOCK may be associated with poor morning gastric motility, and may have a combinatorial effect with PER3. PMID: 25775462
    34. CLOCK 3111 T/C SNP interacts with emotional eating behavior to modulate total weight loss. PMID: 24905098
    35. these findings suggest that sumoylation plays a critical role in the spatiotemporal co-activation of CLOCK-BMAL1 by CBP for immediate-early Per induction and the resetting of the circadian clock. PMID: 26164627
    36. the circadian gene hClock promoted CRC progression and inhibit tumor cell apoptosis in vitro and in vivo, while silencing hClock was able to reverse this effect. PMID: 25625359
    37. PASD1 is a circadian bHLH-PAS paralog repressor of CLOCK protein expression. PMID: 25936801
    38. The observed interaction effects provide converging evidence that the clock gene and OXT/AVP systems are intertwined and contribute to human prosociality. PMID: 25309987
    39. There is not a significant difference in the expression of CLOCK, BMAL1, and PER1 in buccal epithelial cells of patients with essential arterial hypertension regardless of patient genotype. PMID: 25070164
    40. The CLOCK 3111T/C polymorphism was not significantly associated with overweight or sleep duration. PMID: 24818524
    41. CLOCK polymorphisms are associated with increased susceptibility of schizophrenic patients to restless legs syndrome PMID: 24824748
    42. The results of this study present no evidence for an association of CLOCK polymorphisms with juvenile myoclonic epilepsy. PMID: 24892753
    43. Data suggest that influence of obesity-associated CLOCK SNPs (rs12649507, rs6858749) on sleep duration and macronutrient intake can be ameliorated via habitual longer sleep duration and favorable dietary profile (lower protein; higher PUFA). PMID: 25527757
    44. Two single nucleotide polymorphisms in RORA were associated with breast cancer in the whole sample and among postmenopausal women, and we also reported an association with CLOCK, RORA, and NPAS2 in the analyses at the gene level PMID: 24919398
    45. A population specific variation of MTHFR and hCLOCK genes also highlights ethnicity specific risk management. PMID: 24510388
    46. SNP (rs6855837) in the CLOCK gene is significant correlation with genotype and allele frequency in lung cancer. PMID: 24821610
    47. E2 promoted the binding of ERalpha to the EREs (estrogen-response elements) of CLOCK promoter, thereby up-regulating the transcription of CLOCK PMID: 24789043
    48. data support the notion that a chronic consumption of a healthy diet may play a contributing role in triggering glucose metabolism by interacting with the rs1801260 SNP at CLOCK gene locus in metabolic syndrome patients PMID: 24328727
    49. No association with SNPs or haplotypes of the CLOCK gene was observed in prophylactic lithium response. PMID: 24636202
    50. This study failed to show a mediating role of evening preference, ongoing efforts are needed to identify the mechanisms by which the CLOCK gene determines ADHD-related traits. PMID: 24068320

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  • 亚细胞定位:
    Nucleus. Cytoplasm. Cytoplasm, cytosol.
  • 组织特异性:
    Hair follicles (at protein level). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine, colon, leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in testis
  • 数据库链接:

    HGNC: 2082

    OMIM: 601851

    KEGG: hsa:9575

    STRING: 9606.ENSP00000308741

    UniGene: Hs.436975