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CLIP3 Antibody

  • 货号：
    CSB-PA001708
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of A549 cells using CLIP3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q96DZ5
  • 基因名：
    CLIP3
  • 别名：
    1500005P14Rik antibody; AI844915 antibody; CAP GLY domain containing linker protein 3 antibody; CAP-Gly domain-containing linker protein 3 antibody; CLIP 170 related 59 kDa protein antibody; CLIP-170-related 59 kDa protein antibody; clip3 antibody; CLIP3_HUMAN antibody; CLIPR 59 antibody; CLIPR-59 antibody; CLIPR59 antibody; Cytoplasmic linker protein 170 related 59 kDa protein antibody; Cytoplasmic linker protein 170-related 59 kDa protein antibody; Restin like 1 antibody; RSNL1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CLIP3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes.
  • 基因功能参考文献：
    1. this study indicates that inhibition of miRNA-593-3p by insulin promotes glucose metabolism through the regulation of Slc38a1 and CLIP3 expression, and provides a new insight into the role and mechanism of insulin-induced glycolysis. PMID: 27613819
    2. CLIPR-59 interacts with Spy1 resulting in its decreased association with a de-ubiquitinating enzyme in glioblastoma cells. PMID: 26017671
    3. CLIPR-59 modulates ubiquitination of RIP1, resulting in the formation of Complex-II and thus promoting Caspase-8 activation to induce apoptosis by TNF-alpha. PMID: 22297296
    4. CLIPR-59 may act as a typical chaperone, allowing a prompt interaction between tubulin and the raft component GD3 during cell apoptosis triggered by CD95/Fas PMID: 20052288
    5. play an important role in membrane-microtubule interactions. PMID: 11854307
    6. CLIPR-59 prevents microtubule-raft interactions PMID: 15262990

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor. Cytoplasm. Golgi apparatus, Golgi stack. Note=Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae.
  • 数据库链接：

    HGNC: 24314

    OMIM: 607382

    KEGG: hsa:25999

    STRING: 9606.ENSP00000353732

    UniGene: Hs.466539