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CLIP2 Antibody

  • 货号：
    CSB-PA871393LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat brain tissue, Mouse brain tissue
      All lanes: CLIP2 antibody at 3.2μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 116, 112 kDa
      Observed band size: 116 kDa
    • Immunofluorescence staining of A549 cells with CSB-PA871393LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CLIP2 Polyclonal antibody
  • Uniprot No.：
    Q9UDT6
  • 基因名：
    CLIP2
  • 别名：
    CAP GLY domain containing linker protein 2 antibody; CAP-Gly domain-containing linker protein 2 antibody; CLIP 115 antibody; CLIP antibody; CLIP-115 antibody; Clip2 antibody; CLIP2_HUMAN antibody; cytoplasmic linker 2 antibody; Cytoplasmic linker protein 115 antibody; Cytoplasmic linker protein 2 antibody; KIAA0291 antibody; MGC11333 antibody; restin antibody; Similar to RESTIN (CYTOPLASMIC LINKER PROTEIN 170 ALPHA 2) antibody; WBSCR3 antibody; WBSCR4 antibody; Williams Beuren syndrome chromosome region 3 antibody; Williams Beuren syndrome chromosome region 4 antibody; Williams-Beuren syndrome chromosomal region 3 protein antibody; Williams-Beuren syndrome chromosomal region 4 protein antibody; WSCR3 antibody; WSCR4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human CAP-Gly domain-containing linker protein 2 protein (101-217AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CLIP2 Antibody (CSB-PA871393LA01HU)，的标记方式是Non-conjugated。对于CLIP2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA871393LB01HU CLIP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA871393LC01HU CLIP2 Antibody, FITC conjugated
    Biotin CSB-PA871393LD01HU CLIP2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations.
  • 基因功能参考文献：
    1. Cross checking with epidemiological estimates and model validation suggests that CLIP2 is a marker of high precision. CLIP2 leaves an imprint in the epidemiological incidence data which is typical for a driver gene. PMID: 27729373
    2. CLIP2 protein expression is elevated in papillary thyroid carcinomas from patients exposed to radioiodine fallout compared with a nonexposed control group. PMID: 25284583
    3. A clear radiation dose-response relationship for the CLIP2 marker expression in post-Chernobyl papillary thyroid carcinomas PMID: 25957251
    4. CLIP2 haploinsufficiency by itself does not lead to the physical or cognitive characteristics of the Williams-Beuren syndrome; GTF2IRD1 and GTF2I are the main genes causing the cognitive defects PMID: 22608712
    5. Data show that gene CLIP2 was specifically overexpressed in the exposed cases. PMID: 21606360

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  • 相关疾病：
    CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region (PubMed:9799601). WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. However, it has been demonstrated that haploinsufficiency of this gene alone is not sufficient to cause any of the cognitive or facial features of WBS (PubMed:22608712).
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton.
  • 数据库链接：

    HGNC: 2586

    OMIM: 603432

    KEGG: hsa:7461

    STRING: 9606.ENSP00000223398

    UniGene: Hs.647018