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CLEC6A Antibody

  • 货号：
    CSB-PA883930
  • 规格：
    ￥880
  • 图片：
    • Western blot analysis of SH-SY5Y 293T using Dectin-2 antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000
    • Western blot analysis of K562 using Dectin-2 antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000
    • Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200
  • 其他：

产品详情

  • Uniprot No.：
    Q6EIG7
  • 基因名：
    CLEC6A
  • 别名：
    C type lectin domain family 6 member A antibody; C type lectin superfamily member 10 antibody; C-type (calcium dependent; carbohydrate-recognition domain) lectin; superfamily member 10 antibody; C-type lectin domain family 6 member A antibody; C-type lectin superfamily member 10 antibody; CLC6A_HUMAN antibody; CLEC4N antibody; CLEC4N; mouse; homolog of antibody; Clec6a antibody; CLECSF10 antibody; DC associated C type lectin 2 antibody; DC-associated C-type lectin 2 antibody; Dectin-2 antibody; Dectin2 antibody; Dendritic cell associated lectin 2 antibody; Dendritic cell-associated C-type lectin 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Dectin-2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses.
  • 基因功能参考文献：
    1. functions in Kupffer cells to mediate the uptake and clearance of cancer cells PMID: 27872290
    2. Data suggest that the specificity and geometry of dectin-2/CLEC6A carbohydrate-binding site provide molecular mechanism for binding of dectin-2 to fungal mannans and also to bacterial lipopolysaccharides, capsular polysaccharides, and lipoarabinomannans that contain mannose-alpha-1--2-mannose disaccharide unit. (CLEC6A = C-type lectin domain containing 6A) PMID: 28652405
    3. these data indicate that mannosylated O-antigens from several Gram-negative bacteria augment TLR4 responses through interaction with Dectin-2. PMID: 27358401
    4. This study showed a genetic association between Dectin-2 and pulmonary cryptococcosis. PMID: 26129889
    5. human plasmacytoid dendritic cells directly recognize A. fumigatus hyphae via Dectin-2 PMID: 25659141
    6. our data show a requirement for Dectin-2 in alveolar macrophage induction of cysteinyl leukotrienes and in the initiation of airway inflammation. PMID: 24129160
    7. The Dectin-2 possess a single extracellular conserved C-type lectin-like domain and are capable of mediating intracellular signalling either directly, through integral signalling domains, or indirectly, by associating with signalling adaptor molecules. PMID: 23606632
    8. human DECTIN-2 has a role in innate immunity PMID: 15810886

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.
  • 数据库链接：

    HGNC: 14556

    OMIM: 613579

    KEGG: hsa:93978

    STRING: 9606.ENSP00000371505

    UniGene: Hs.591147