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CLEC12A Antibody

  • 货号：
    CSB-PA725176ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: C-type lectin domain family 12 member A antibody at 2μg/ml + Mouse skeletal muscle tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 31, 33, 9, 28, 25 kDa
      Observed band size: 31 kDa
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA725176ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    The CLEC12A antibody was raised in rabbits against a partial recombinant protein corresponding to the 66-265 amino acids of the human CLEC12A protein. It exists as an unconjugated IgG isoform. It underwent antigen affinity purification.

    This CLEC12A polyclonal antibody has undergone rigorous quality control in multiple applications, including ELISA, WB, and IHC. And it shows reactivity with human and mouse CLEC12A protein. The CLEC12A protein mainly modulates the immune response, particularly in the regulation of myeloid cell activation and differentiation. It is also involved in the pathogenesis of certain cancers and autoimmune diseases.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CLEC12A Polyclonal antibody
  • Uniprot No.：
    Q5QGZ9
  • 基因名：
  • 别名：
    C-type lectin domain family 12 member A antibody; C-type lectin-like molecule 1 antibody; CL12A_HUMAN antibody; CLEC12A antibody; CLL-1 antibody; DCAL-2 antibody; Dendritic cell-associated lectin 2 antibody; MICL antibody; Myeloid inhibitory C-type lectin-like receptor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human C-type lectin domain family 12 member A protein (66-265AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
  • 基因功能参考文献：
    1. Enumeration of circulating hMICL+ stem cells by flow cytometry can discriminate between myeloproliferative neoplasm phenotypes and holds potential for monitoring disease evolution. PMID: 29427319
    2. CLL-1 is a novel prognostic predictor that could be exploited to supplement the current acute myeloid leukemia prognostic risk stratification system. PMID: 28810819
    3. The CLEC12A is an effective new candidate with great potential for in vivo Ag delivery into mDCs and pDCs, thereby using the specialized functions and cross-talk capacity of these DC subsets to boost tumor-reactive T cell immunity in cancer patients. PMID: 27566820
    4. Due to the absence of CLEC12A on normal haematopoietic stem cells, CLEC12A stem cell immunophenotyping may contribute to diagnosing and monitoring MDS patients and could furthermore add knowledge about disease propagating cells in MDS. PMID: 27612176
    5. We propose the hypothesis that decreased expression of CLEC12A is a common denominator in the hyperinflammatory responses observed in Behcet's syndrome and gout. PMID: 25957656
    6. Upon CLL1-selective binding of this fusion protein, granulocytes acquire additional TRAIL-mediated cytotoxic activity that, importantly, potentiates antibody-mediated cytotoxicity of clinically used therapeutic antibodies PMID: 25760768
    7. We conclude the hMICL/CD123-based MFC assay is a promising MRD tool in AML. PMID: 24152218
    8. There is a potential genetic association of CLEC12A with rheumatoid arthritis (RA). Since CLEC12A encodes for the myeloid inhibitory C-type lectin-like receptor that modulates cytokine synthesis, this receptor may contribute to the pathogenesis of RA. PMID: 22341585
    9. For production of cytotoxic T cells, transgenic DEC-205 and Clec9A, but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants. PMID: 21677141
    10. MICL is a negative regulator of granulocyte and monocyte function PMID: 14739280
    11. the molecular cloning, tissue distribution, and functional characterization of a novel NK cell receptor, KLRL1, from human and mouse dendritic cells [KLRL1] PMID: 15238421
    12. Expression cloning identified the antigen recognized as C-type lectin-like molecule-1, a previously undescribed transmembrane glycoprotein PMID: 15548716
    13. Dendritic-cell (DC)-associated C-type lectin receptors (CLRs) take up antigens to present to T cells and regulate DC functions. PMID: 16239426
    14. human MICL may be involved in the control of myeloid cell activation during inflammation PMID: 16838277
    15. CLL-1 expression is also present on the CD34(+)CD38(-) stem- cell compartment in acute myeloid leukemia PMID: 17609428
    16. mMICL recognises an endogenous ligand in a variety of murine tissues, suggesting that the receptor plays a role in homeostasis PMID: 18350551
    17. Anti-Clec12A mAb alone produced only moderate responses, but these were amplified by coinjecting only small amounts of LPS as a dendritic cell activation agent PMID: 19494282

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein. Note=Ligand binding leads to internalization.
  • 组织特异性：
    Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leuko
  • 数据库链接：

    HGNC: 31713

    OMIM: 612088

    KEGG: hsa:160364

    STRING: 9606.ENSP00000347916

    UniGene: Hs.190519