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CLB2 Antibody

  • 货号：
    CSB-PA326178XA01SVG
  • 规格：
    ￥880
  • 图片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes:CLB2 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 34 kDa
      Observed band size: 34 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) CLB2 Antibody Polyclonal antibody
  • Uniprot No.：
    P24869
  • 基因名：
    CLB2 Antibody
  • 别名：
    G2/mitotic-specific cyclin-2 CLB2 YPR119W P9642.6
  • 宿主：
    Rabbit
  • 反应种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 免疫原：
    Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) CLB2 protein (2-280aa)
  • 免疫原种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
  • 基因功能参考文献：
    1. Data indicate the role of the principal mitotic cyclin gene CLB2 at the end of S phase. PMID: 29279302
    2. Size control seems to be exerted twice, where the G2/M control affects bud size through bud-localized translation of CLB2 mRNA, explaining the dependence of the S-G2-M duration on nutrients. PMID: 25910075
    3. The essential role of nuclear Clb2 is in both survival and adaptation to the DNA damage checkpoint, illustrating a spatially distinct dual function of this mitotic cyclin in the response to DNA damage. PMID: 24300211
    4. Study discovered a pathway that links starvation to control of CLB2 mRNA stability and M phase delay. Dbf2 phosphorylates and activates the arginine methyltransferase Hmt1. In turn, Hmt1 methylates hnRNPs, promoting their nuclear localization, their cotranscriptional association with CLB2 mRNA, and the stability of CLB2 mRNA. PMID: 23706744
    5. These observations differentiate the functions of CLB1, CLB2, and CLB3 at mitotic exit.Actin ring formation is disrupted by deletion of CLB2 in cdc14-arrested cells PMID: 21784165
    6. The inhibition of mitotic exit in budding yeast using graded levels of stable mitotic cyclin (Clb2), is investigated. PMID: 19920813
    7. transcription factors for CLB2 are involved in the cell wall integrity checkpoint system and suggest that there are multiple regulation pathways of the checkpoint. PMID: 20057164
    8. CDK interaction with the amino-terminal domain of Cdc6 is mediated by the cyclin subunit Clb2 PMID: 15496876
    9. development of a model to generate biochemical predictions for Clb2 levels, asynchronous as well as through the cell cycle, as the Clb2 overexpression threshold is approached PMID: 15716353
    10. cytoplasmic Clb2is required for timely inactivation of Swe1 at the G2/M transition, and bud morphogenesis. PMID: 17033818
    11. The subcellular localization of the mitotic cyclin Clb2 is one of the key determinants of its biological function. PMID: 17264146
    12. functional antagonism between Rot1 and Clb2 is supported by genetic and biochemical data, which indicate that Rot1 is implicated in Clb2 protein degradation PMID: 17606994
    13. The inactivation of the Sin3 histone deacetylase complex bypasses the essential role of Ndd1 in cell cycle progression. Sin3 and its catalytic subunit Rpd3 associate with the CLB2 promoter during the G1 phase of the cell cycle. PMID: 17908798
    14. Cells expressing partially stable Clb2 were particularly sensitive to different stresses, possibly due to reduced Sic1 levels. PMID: 19713762

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  • 蛋白家族：
    Cyclin family, Cyclin AB subfamily
  • 数据库链接：

    KEGG: sce:YPR119W

    STRING: 4932.YPR119W