Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. CIZ1 Antibody

CIZ1 Antibody

  • 中文名称：
    CIZ1兔多克隆抗体
  • 货号：
    CSB-PA910444
  • 规格：
    ￥1100
  • 图片：
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: CSB-PA910444(CIZ1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    Q9ULV3
  • 基因名：
    CIZ1
  • 别名：
    CDKI antibody; CDKN1A-interacting zinc finger protein 1 antibody; Cip1-interacting zinc finger protein antibody; CIZ1 antibody; CIZ1_HUMAN antibody; cyclin dependent inhibitor 1A antibody; LSFR1 antibody; Melanoma differentiation-associated protein antibody; NP94 antibody; Nuclear protein NP94 antibody; OPHN3 antibody; P21 antibody; Zinc finger protein 356 antibody; ZNF356 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human CIZ1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May regulate the subcellular localization of CIP/WAF1.
  • 基因功能参考文献：
    1. data reveal that CIZ1 plays a major role in ensuring stable association of Xist RNA within the Xi territory. PMID: 28923964
    2. CIZ1 activates YAP/TAZ signaling in human hepatocellular carcinoma cells. PMID: 26515335
    3. CIZ1 is a kinase sensor that promotes initiation of DNA replication at low kinase levels, when in a hypophosphorylated state that is permissive for cyclin-A-CDK2 interaction and delivery to licensed origins. PMID: 25736292
    4. The results of this study showed CIZ1 will play a less important role in dystonia patient diagnosis than previously thought because variants of unclear significance are observed in approximately 1% of adult-onset sporadic dystonia patients in Germany. PMID: 25778706
    5. Our study demonstrated that CIZ1 played an oncogenic role in the progression of GBC and CIZ1 might be a promising target for the treatment of GBC PMID: 25427641
    6. This study suggested that No mutations in CIZ1 in twelve adult-onset primary cervical dystonia families. PMID: 23813719
    7. CIZ1 may be involved in colon cancer progression by regulating cell proliferation, cell cycle, apoptosis and colony formation. PMID: 24126760
    8. Variant Ciz1 is a strong candidate for a cancer-specific single marker capable of identifying early-stage lung cancer. PMID: 23074256
    9. Mutations in CIZ1 may cause adult onset, primary cervical dystonia PMID: 22447717
    10. alternatively spliced variant of Ciz1 is associated with cancer. PMID: 20831784
    11. data indicate that Ciz1 is localized in the nucleus and is expressed in a wide range of tissues, especially the pancreas and the brain; formulated a consensus DNA sequence, ARYSR(0-2)YYAC, recognized by Ciz1 PMID: 12824700
    12. Findings revealed the inherent role of Ciz1, a novel DNA binding and ER coactivator, in amplifying estrogenic responses and promoting breast cancer tumorigenesis. PMID: 17108141
    13. conditional exclusion of exon 4 influences the spatial distribution of the Ciz1 protein within the nucleus, showing that CIZ1 alternative splicing could influence organized patterns of DNA replication PMID: 17508423
    14. Ciz1 is a nuclear zinc finger protein interacting with p21, and is a DNA replication factor. The region of Ciz1 necessary for the interaction with ERH spans residues 531-644, encompassing its first zinc finger motif PMID: 18081865
    15. An isoform of CIZ1 which lacks a glutamine-rich region, due to alternative splicing in exon 8, is upregulated in Alzheimer's brains relative to the full-length CIZ1 protein. PMID: 18583151

    显示更多

    收起更多

  • 相关疾病：
    Defects in CIZ1 may be a cause of adult onset primary cervical dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Cervical dystonia or spasmodic torticollis, the most common form of focal dystonia, is characterized by involuntary contractions of the neck muscles, which produce abnormal posturing of the head upon the trunk.
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 16744

    OMIM: 611420

    KEGG: hsa:25792

    STRING: 9606.ENSP00000362029

    UniGene: Hs.212395