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CIDEB Antibody

  • 货号：
    CSB-PA001649
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HT-29 cells using CIDE-B Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9UHD4
  • 基因名：
    CIDEB
  • 别名：
    Cell death activator CIDE B antibody; Cell death activator CIDE-B antibody; Cell death inducing DFFA like effector B antibody; Cell death-inducing DFFA-like effector B antibody; CIDEB antibody; CIDEB_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CIDE-B.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Activates apoptosis.; (Microbial infection) Involved in Hepatatis C virus (HCV) assembly and required for HCV entry into hepatocytes.
  • 基因功能参考文献：
    1. High Cideb expression is associated with Ulcerative Colitis. PMID: 28719542
    2. CIDEB interacts with the HCV NS5A protein, and the N terminus of CIDEB and the domain I of NS5A are involved in this interaction. PMID: 27282740
    3. these data revealed that Cideb plays an important role in controlling intestinal chylomicron lipidation. PMID: 24831470
    4. this study shows that C5a signaling induces apoptosis in brain vascular endothelial cells in experimental lupus through activation of CIDEB PMID: 27213693
    5. CIDEB downregulation may contribute to HCV-induced hepatic steatosis PMID: 26865724
    6. CIDEB can act as an anti-HCV host factor and contribute to altered triglyceride homeostasis. PMID: 24980280
    7. s found CIDEB to be an essential cofactor for hepatitis C virus entry into hepatocytes. PMID: 24829338
    8. this work highlights CIDEB's role in lipid droplet (LD) fusion, and presents a new model system to study the PGC-1alpha/CIDEB pathway's role in LD dynamics and the VLDL pathway. PMID: 24161736
    9. CIDE proteins expression correlate with tumor and survival characteristics in patients with renal cell carcinoma. PMID: 23475172
    10. A novel mechanism for the cell-specific transcription of the human CIDE-B gene, which involves epigenetic and genetic control at separate respective promoters is reported. PMID: 16248853

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  • 组织特异性：
    Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen.
  • 数据库链接：

    HGNC: 1977

    OMIM: 604441

    KEGG: hsa:27141

    STRING: 9606.ENSP00000258807

    UniGene: Hs.642693