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CIB2 Antibody

  • 货号：
    CSB-PA005427LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of Hela cells using CSB-PA005427LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CIB2 Polyclonal antibody
  • Uniprot No.：
    O75838
  • 基因名：
    CIB2
  • 别名：
    Calcium and integrin binding protein 2 antibody; Calcium and integrin-binding family member 2 antibody; Cib2 antibody; CIB2_HUMAN antibody; DNA dependent protein kinase interacting protein 2 antibody; Kinase interacting protein 2 antibody; Kinase-interacting protein 2 antibody; KIP 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Calcium and integrin-binding family member 2 protein (65-164AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CIB2 Antibody (CSB-PA005427LA01HU)，的标记方式是Non-conjugated。对于CIB2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA005427LB01HU CIB2 Antibody, HRP conjugated ELISA
    FITC CSB-PA005427LC01HU CIB2 Antibody, FITC conjugated
    Biotin CSB-PA005427LD01HU CIB2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release. May be involved in the mechanotransduction process.
  • 基因功能参考文献：
    1. this study identifies CIB1 and CIB2 as host helper factors for HIV-1 replication that are required for optimal receptor-mediated viral entry PMID: 27489023
    2. results suggest that GJB2 and CIB2 are common cause of hearing loss in different Pakistani ethnicities PMID: 29086887
    3. High CIB2 expression is associated with ovarian Cancer. PMID: 28729416
    4. Novel homozygous missense variant c.196C>T and compound heterozygous variants, c.[97C>T];[196C>T], were associated with nonsyndromic deafness. PMID: 26173970
    5. We identified a novel variant (rs7164338) on chromosome 15q25.1 in the CIB2 associated with lower pulse wave velocity. PMID: 26378684
    6. CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family PMID: 26426422
    7. Data indicate that that CIB2 localizes to stereocilia and interacts with the USH proteins myosin VIIa and whirlin, suggesting CIB2 is a Ca2+-buffering protein essential for calcium homeostasis in the mechanosensory stereocilia of inner ear hair cells. PMID: 24022220
    8. Consistent with molecular modeling predictions of calcium binding, CIB2 significantly decreased the ATP-induced calcium responses in heterologous cells, whereas mutations in deafness DFNB48 altered CIB2 effects on calcium responses PMID: 23023331
    9. CIB2, as binding partners for the integrin alphaIIb subunit, which suggests that they are potentially involved in regulating integrin alphaIIb subunit activation. PMID: 22779914

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  • 相关疾病：
    Deafness, autosomal recessive, 48 (DFNB48); Usher syndrome 1J (USH1J)
  • 亚细胞定位：
    Cytoplasm. Cell projection, stereocilium. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Cell membrane, sarcolemma.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 24579

    OMIM: 605564

    KEGG: hsa:10518

    STRING: 9606.ENSP00000258930

    UniGene: Hs.129867