CIART Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) CIART Polyclonal antibody
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Uniprot No.:Q8N365
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基因名:CIART
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别名:CIART antibody; C1orf51Circadian-associated transcriptional repressor antibody; ChIP-derived repressor of network oscillator antibody; Chrono antibody; Computationally highlighted repressor of the network oscillator antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human Circadian-associated transcriptional repressor protein (1-385AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,CIART Antibody (CSB-PA850790LA01HU),的标记方式是Non-conjugated。对于CIART Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, IHC
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推荐稀释比:
Application Recommended Dilution IHC 1:20-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CA...显示更多
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基因功能参考文献:
- Study shows that:1- Chrono is a circadian clock gene whose transcription exhibits a robust circadian oscillation. 2- Is is a repressor of circadian transcriptional/translational feedback loops. 3- It may function to link epigenetic control mechanisms to stress responses. [review] PMID: 28010116
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亚细胞定位:Nucleus. Nucleus, PML body.
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数据库链接:
HGNC: 25200
OMIM: 615782
KEGG: hsa:148523
STRING: 9606.ENSP00000290363
UniGene: Hs.54680