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  4. CHTOP Antibody

CHTOP Antibody

  • 货号：
    CSB-PA003619GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y3Y2
  • 基因名：
    CHTOP
  • 别名：
    C1orf77 antibody; chromatin target of chromatin target of PRMT1 protein antibody; Chromatin target of PRMT1 antibody; Chromatin target of PRMT1 protein antibody; Chromosome 1 open reading frame 77 antibody; CHTOP antibody; CHTOP_HUMAN antibody; DKFZp547E1010 antibody; FL- RP1-178F15.2 antibody; FL-SRAG antibody; FOP antibody; Friend of PRMT1 antibody; Friend of PRMT1 protein antibody; HT031 antibody; MGC131924 antibody; MGC86949 antibody; OTTHUMP00000035122 antibody; OTTHUMP00000035123 antibody; Pp7704 antibody; RP1 178F15.2 antibody; Small arginine- and glycine-rich protein antibody; Small protein rich in arginine and glycine antibody; SRAG antibody; SRAG-3 antibody; SRAG-5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human C1orf77
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis.; Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity.
  • 基因功能参考文献：
    1. the cellular level of Chtop is autoregulated via Int2 retention of its own mRNA, which subsequently undergoes NMD. PMID: 27683223
    2. Results suggest that 5hmC plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of cancer-related genes. PMID: 25284789
    3. Chtop is a component of the dynamic TREX mRNA export complex that, along with Alyref, activates the ATPase and RNA helicase activities of Uap56. PMID: 23299939
    4. The recently identified chromatin factor Friend of Prmt1 (FOP) is a critical modulator of gamma-globin gene expression. PMID: 20688955
    5. Fop is tightly associated with chromatin, and that it is modified by both asymmetric and symmetric arginine methylation in vivo. Fop plays an important role in the ligand-dependent activation of estrogen receptor target genes, including TFF1 (pS2). PMID: 19858291
    6. The reduction in SRAG protein that occurs in proliferating cells was mapped with inhibitors to the G(2)/M phase of the cell cycle. As expected, the overexpression of SRAG reduced the percentage of cells in the G(2)/M phase and increased cell death. PMID: 19254951

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  • 亚细胞定位：
    Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle.
  • 组织特异性：
    Expressed in an erythroid progenitor cell line derived from peripheral blood. Expressed in glioblastoma cells.
  • 数据库链接：

    HGNC: 24511

    OMIM: 614206

    KEGG: hsa:26097

    STRING: 9606.ENSP00000357683

    UniGene: Hs.611057