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CHRNA10 Antibody

  • 货号：
    CSB-PA968134
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA968134(CHRNA10 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA968134(CHRNA10 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9GZZ6
  • 基因名：
    CHRNA10
  • 别名：
    Acetylcholine receptor, neuronal nicotinic, alpha-10 subunit antibody; ACH10_HUMAN antibody; Alpha 10 nAChR antibody; Cholinergic receptor nicotinic alpha 10 antibody; Cholinergic receptor, neuronal nicotinic, alpha polypeptide 10 antibody; Cholinergic receptor, nicotinic, alpha polypeptide 10 antibody; CHRNA 10 antibody; CHRNA10 antibody; NACHR alpha 10 antibody; NACHR alpha-10 antibody; NACHRA10 antibody; Neuronal acetylcholine receptor protein subunit alpha 10 antibody; Neuronal acetylcholine receptor subunit alpha-10 antibody; Nicotinic acetylcholine receptor subunit alpha 10 antibody; Nicotinic acetylcholine receptor subunit alpha-10 antibody; OTTHUMP00000013620 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human CHRNA10
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
  • 基因功能参考文献：
    1. A two order of magnitude species difference is reported in potency of alpha-conotoxin RgIA for rat versus human alpha9alpha10 nAChR. PMID: 22774872
    2. CHRNA10 may have a role in "dizziness" in response to tobacco PMID: 19760673
  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-10/CHRNA10 sub-subfamily
  • 组织特异性：
    Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.
  • 数据库链接：

    HGNC: 13800

    OMIM: 606372

    KEGG: hsa:57053

    STRING: 9606.ENSP00000250699

    UniGene: Hs.732806