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  4. CHRM1 Antibody

CHRM1 Antibody

  • 货号：
    CSB-PA576885
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA576885(CHRM1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA576885(CHRM1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P11229
  • 基因名：
  • 别名：
    CHRM1; Muscarinic acetylcholine receptor M1
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human CHRM1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
  • 基因功能参考文献：
    1. The study was focused on the human mAChR1 receptor for which a presumably reliable model was generated using the congener mAChR3 as the template along with a second less reliable model based on the distant beta2-AR template. The second model was then utilized to produce the chimeras by combining the conformations of its Pro-containing helices (i.e., TM4, TM5, TM6 and TM7 with 16 modeled chimeras). PMID: 27490167
    2. he discovery of a receptor homolog of human mAChR1 on Acanthamoeba with future studies planned to show its expression and binding to cholinergic agonist and antagonist would help clarify its role in the biology of this protist pathogen. PMID: 27601178
    3. Receptor Species-dependent Desensitization Controls KCNQ1/KCNE1 K+ Channels as Downstream Effectors of Gq Protein-coupled Receptors.( PMID: 27834678
    4. There were no significant associations between CHRM1 SNPs and autonomic nervous system activity in patients with schizophrenia on high-dose antipsychotics. PMID: 27923235
    5. changes in membrane cholesterol concentration differentially impact preferential and non-preferential M1 and M3 receptor signaling PMID: 24821386
    6. The rs2067477 muscarinic M1 receptor genotype is associated with grey matter volume in schizophrenia. PMID: 26481978
    7. crystal structures of the M1 and M4 muscarinic receptors bound to the inverse agonist, tiotropium PMID: 26958838
    8. this study highlights how the properties of affinity and cooperativity can be differentially modified on a common structural scaffold and identifies molecular features that can be exploited to tailor the development of M1 mAChR-targeting PAMs. PMID: 25326383
    9. CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients. PMID: 24430298
    10. the levels were comparable for complexes containing GluR2, GluR3 and GluR4 as well as 5-HT1A. Moreover, the levels of complexes containing muscarinic AChR M1, NR1 and GluR1 were significantly increased in male patients with AD. PMID: 24292102
    11. We show that BQCA potentiates agonist-induced beta-arrestin recruitment to M1 mAChRs. PMID: 24753247
    12. In patients with schizophrenia, both cell body staining and elevated M1 muscarinic receptor reactivity correlated with higher symptom scores. PMID: 24636402
    13. demonstrate that activation of M1 muscarinic acetylcholine receptor augments the restitution of epithelial barrier function in T84 cell monolayers after ethanol-induced epithelial injury, via ERK-dependent phosphorylation of focal adhesion kinase PMID: 24365239
    14. Mutation of amino acid residues that form the orthosteric binding pocket caused a loss of carbachol response that could be rescued by BQCA. PMID: 24443568
    15. Results show that downregulation of cholinergic receptor M1 by histone H3K9me3 impairs calcium signally and contributes to the pathogenesis of Huntington's disease. PMID: 23455440
    16. Decreased muscarinic M1 receptor radioligand binding is found in the cerebral cortex of schizophrenic patients. PMID: 22338582
    17. M1-mAChRs function at both surface and intracellular sites in telencephalon neurons including the hippocampus PMID: 23678982
    18. The fluorescent compounds inherit bitopic properties from a linker-guided positioning of their Bodipy moiety within the M1 allosteric vestibule. PMID: 23604140
    19. Autoantibodies purified from the sera of breast cancer patients activate muscarinic acetylcholine receptors in tumor cells. PMID: 23460876
    20. A breakdown in gene promoter methylation control of CHRM1 expression contributes to the global pathophysiology of schizophrenia. PMID: 23423139
    21. These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved. PMID: 22990911
    22. Collectively, the results of this study demonstrated that SOD1 could activate a transductional pathway through the involvement of M1 muscarinic receptor. PMID: 23147108
    23. These data indicate that EGFR and PKC are involved in mAChR-mediated activation of ERK1/2 and RSK and the subsequent proliferation of SNU-407 colon cancer cells. PMID: 22865467
    24. CHRM1 sequence is associated with alterations in some aspects of executive function. Post-mortem study indicates this is not simply due to altered expression at the mRNA level, suggesting sequence alteration may affect the functionality of the CHRM1. PMID: 22391213
    25. Here we found that M1 Muscarinic acetylcholine receptor (M1 mAChR), an important G protein-coupled receptor involved in cholinergic neuronal activity, can interact with BACE1 and mediate its proteosomal degradation. PMID: 22450048
    26. The binding mode of MT7 and human muscarinic acetylcholine receptor 1 consists of three interaction regions in five residue interaction clusters. PMID: 22571431
    27. Binding properties of human muscarinic M1 receptor in stably transfected Chinese hamster ovary cells is significantly enhanced after supplementation, probably by facilitating receptor-mediated G protein activation. PMID: 22146060
    28. docking calculations structurally support the high affinity and selectivity of the MT7-human M1 muscarinic receptor interaction and highlight the atypical mode of interaction of this allosteric ligand on its G protein-coupled receptor target. PMID: 21685390
    29. analysis of the long-term effects of xanomeline on the M(1) muscarinic acetylcholine receptor PMID: 21203415
    30. Distribution of M1 receptors in human colon. PMID: 20146726
    31. M1 receptor plays an important role in the maintenance of function of retinal pigment epithelium. PMID: 17415969
    32. Data show that two-color TIRFM established the dynamic nature of dimer formation with M(1) receptors undergoing interconversion between monomers and dimers on the timescale of seconds. PMID: 20133736
    33. increased inattention scores (Conners' teacher-rating scale) and lower l-MR associated with increased score for oppositional-defiant disorder. PMID: 19863190
    34. This study demonistred that in subgroup of subjects with schizophrenia decreased cortical muscarinic acetylcholine receptor M1. PMID: 18317461
    35. Muscarinic cholinoceptor activation by pilocarpine triggers apoptosis in human skin fibroblast cells. PMID: 19927300
    36. Fifteen single nucleotide polymorphisms (SNPs) of CHRM1 have been discovered, 9 of which are located in the coding region of the receptor; of these, 8 represent synonymous SNPs, indicating that CHRM1 is highly conserved in humans. PMID: 12049494
    37. 28% decrease in post-mortem levels of steady-state cortical muscarinic 1 receptor cDNA in schizophrenia patient samples relative to controls PMID: 12707929
    38. role of M1 and M2 muscarinic receptors expressed by human L cells in the control of GLP-1 secretion. PMID: 12810581
    39. In conclusion, autoantibodies to CHRM1 were detected in a large number of CFS patients and were related to CFS symptoms. PMID: 12851722
    40. M1- and M3- but not M2- or M4-AchR signals activate HIF-1 by both stabilization and synthesis of HIF-1alpha and by inducing the transcriptional activity of HIF-1alpha. PMID: 15280370
    41. mRNA of muscarinic acetylcholine receptor-1 is expressed in human scleral fibroblasts. PMID: 16318751
    42. All three of the Kir2 channels are similarly inhibited by m1 muscarinic receptor stimulation through calcium-dependent activation of the small GTPase Rho. PMID: 16328454
    43. Increased phosphorylation of M1 and M2 mAChRs underlies sequestration of these receptors after transient hypoxia. Distinct pathways involving CK1alpha and GRK2 mediated sequestration of M1 and M2 mAChRs after transient hypoxic-induced oxidative stress. PMID: 16336219
    44. Data demonstrate that M(1), M(2), and M(3) muscarinic acetylcholine receptors (mAChR)can form homo- and heterodimers in living cells, and suggest that heterodimerization plays a role in the mechanism of mAChR long term regulation. PMID: 16368694
    45. Data show that intracellular zinc uptake in SK-SH-SY5Y cells is controlled by M1-mAChR mediated signalling pathways and that zinc may act as a cofactor for transcriptional regulation of zinc finger genes such as PNUTS. PMID: 16406470
    46. MT7 toxin interacts with hM1 receptor at a specific allosteric site, which may partially overlap those identified previously for "classic" or "atypical" allosteric agents. PMID: 16439611
    47. Association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. PMID: 16874522
    48. mAChR subtypes (m1 to m5) presents in human scleral fibroblasts at both mRNA and protein levels. PMID: 16877267
    49. This study provides the structural insight for improved understanding of M1 receptor and its binding sites. PMID: 16902941
    50. Gene Coding the human cholinergic receptor muscarinic-1 is an important susceptibility locus for asthma at chromosome 11q13. PMID: 16931638

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Muscarinic acetylcholine receptor subfamily, CHRM1 sub-subfamily
  • 数据库链接：

    HGNC: 1950

    OMIM: 118510

    KEGG: hsa:1128

    STRING: 9606.ENSP00000306490

    UniGene: Hs.632119