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CHI3L2 Antibody

  • 货号：
    CSB-PA620893ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: CHI3L2 antibody at 4μg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: Rat brain tissue
      Lane 3: A431 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 44, 35, 43 kDa
      Observed band size: 44 kDa
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA620893ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA620893ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CHI3L2 Polyclonal antibody
  • Uniprot No.：
    Q15782
  • 基因名：
  • 别名：
    CH3L2_HUMAN antibody; CHI3L2 antibody; Chitinase 3 like 2 antibody; Chitinase-3-like protein 2 antibody; Chondrocyte protein 39 antibody; OTTHUMP00000014028 antibody; YKL 39 antibody; YKL-39 antibody; YKL39 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Chitinase-3-like protein 2 protein (27-390AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity.
  • 基因功能参考文献：
    1. This study shown that CHI3L2 is regulated differently in healthy and late onset Alzheimer"s disease brain depending on the sex. PMID: 27653898
    2. Structural analysis demonstrates that YKL-39 interacts with chitooligosaccharides through hydrogen bonds and hydrophobic interactions. Thermodynamic analysis indicates that binding of chitooligosaccharide to YKL-39 is mainly driven by enthalpy. PMID: 25477513
    3. These data suggest that hYKL-39 is a novel growth and differentiation factor involved in cartilage homeostasis. PMID: 23291184
    4. YKL-39 possesses a chitinase-like fold, but lacks key active-site residues required for catalysis. PMID: 22742450
    5. ERK1/2 phosphorylation by CHI3L2 inhibits cell mitogenesis and proliferation. PMID: 22211103

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Glycosyl hydrolase 18 family
  • 组织特异性：
    Highest expression in chondrocytes, followed by synoviocytes, lung and heart. Not detected in spleen, pancreas, and liver. May also be expressed in developing brain and placenta.
  • 数据库链接：

    HGNC: 1933

    OMIM: 601526

    KEGG: hsa:1117

    STRING: 9606.ENSP00000358763

    UniGene: Hs.514840