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CHCHD3 Antibody

  • 货号：
    CSB-PA873679ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: CHCHD3 antibody at 1.67µg/ml
      Lane 1: Mouse lung tissue
      Lane 2: HepG2 whole cell lysate
      Lane 3: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 26 kDa
      Observed band size: 26 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA873679ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA873679ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CHCHD3 Polyclonal antibody
  • Uniprot No.：
    Q9NX63
  • 基因名：
    CHCHD3
  • 别名：
    CHCH3_HUMAN antibody; CHCHD 3 antibody; Chchd3 antibody; Coiled coil helix coiled coil helix domain containing 3 antibody; Coiled coil helix coiled coil helix domain containing protein 3 mitochondrial antibody; Coiled-coil-helix-coiled-coil-helix domain-containing protein 3 antibody; FLJ20420 antibody; MINOS3 antibody; mitochondrial antibody; Mitochondrial inner membrane organizing system 3 antibody; PPP1R22 antibody; Protein phosphatase 1 regulatory subunit 22 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human MICOS complex subunit MIC19 protein (1-227AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.
  • 基因功能参考文献：
    1. Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50. PMID: 28808085
    2. The findings suggest that Mic19 is a redox-dependent regulator of mitochondrial contact site and crista organizing system complex function. PMID: 26416881
    3. both the myristoylation and the CHCH domain are essential for the import and mitochondrial localization of ChChd3. Once imported, ChChd3 binds to Mia40 for further folding and assembly into macromolecular complexes. PMID: 23019327
    4. ChChd3 is a scaffolding protein that stabilizes protein complexes involved in maintaining crista architecture and protein import and is thus essential for maintaining mitochondrial structure and function. PMID: 21081504
    5. mitofilin helps regulate mitochondrial morphology and at least four of the associated proteins (metaxins 1 and 2, SAM50 and CHCHD3) have been implicated in protein import PMID: 17624330

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  • 亚细胞定位：
    Mitochondrion inner membrane; Lipid-anchor; Intermembrane side. Cytoplasm. Nucleus. Mitochondrion.
  • 蛋白家族：
    MICOS complex subunit Mic19 family, Metazoan Mic19 subfamily
  • 组织特异性：
    Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue.
  • 数据库链接：

    HGNC: 21906

    OMIM: 613748

    KEGG: hsa:54927

    STRING: 9606.ENSP00000262570

    UniGene: Hs.655010