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CHAD Antibody

  • 货号：
    CSB-PA005310GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O15335
  • 基因名：
  • 别名：
    Cartilage leucine rich protein antibody; Cartilage leucine-rich protein antibody; Chad antibody; CHAD_HUMAN antibody; Chondroadherin antibody; Chondroadherin proteoglycan antibody; SLRR4A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CHAD
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation.
  • 基因功能参考文献：
    1. crystal structures at ~2.2A resolution of human fibromodulin and chondroadherin. PMID: 28215822
    2. number of cells adhering via their beta(1) integrin receptor to collagen type II or chondroadherin was profoundly and rapidly enhanced by the addition of the heparin-binding peptide PMID: 23172228
    3. chondroadherin interaction with cells may be central for maintaining the adult chondrocyte phenotype and cartilage homeostasis. PMID: 21127050
    4. Changes in CHAD abundance or structure could be associated with the pathologic changes occurring in the scoliotic IVD. PMID: 19525844
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Small leucine-rich proteoglycan (SLRP) family, SLRP class IV subfamily
  • 组织特异性：
    Present in chondrocytes at all ages.
  • 数据库链接：

    HGNC: 1909

    OMIM: 602178

    KEGG: hsa:1101

    STRING: 9606.ENSP00000258969

    UniGene: Hs.97220