CGNL1 Antibody
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中文名称:CGNL1兔多克隆抗体
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货号:CSB-PA005304GA01HU
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规格:¥3,900
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其他:
产品详情
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Uniprot No.:Q0VF96
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基因名:CGNL1
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别名:Cgnl1 antibody; CGNL1_HUMAN antibody; Cingulin like 1 antibody; Cingulin-like protein 1 antibody; FLJ14957 antibody; JACOP antibody; Junction-associated coiled-coil protein antibody; KIAA1749 antibody; MGC138254 antibody; Paracingulin antibody
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宿主:Rabbit
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反应种属:Human,Mouse,Rat
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免疫原:Human CGNL1
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免疫原种属:Homo sapiens (Human)
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抗体亚型:IgG
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纯化方式:Antigen Affinity purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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产品提供形式:Liquid
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应用范围:ELISA,WB
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Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons.
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基因功能参考文献:
- demonstrate in a postnatal retinal vascular development model in mice that Cgnl1 function is crucial for sustaining neovascular growth and stability PMID: 29016873
- Results indentify plausible candidates include non-recurrent deletions at the glutamate transporter gene SLC1A1, a CNV locus recently suggested to be involved in schizophrenia through linkage analysis, and duplications at 1p36.33 and CGNL1. PMID: 24163246
- ZO-1 and PLEKHA7 are paracingulin-interacting proteins that are involved in its recruitment to epithelial tight and adherens junctions, respectively PMID: 21454477
- Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions PMID: 18653465
- This paper studied the mouse JACOP protein and found that the JACOP protein has structural and functional similarities to cingulin. PMID: 15292197
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相关疾病:Aromatase excess syndrome (AEXS)
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亚细胞定位:Cell junction, tight junction.
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蛋白家族:Cingulin family
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组织特异性:Smooth muscle, spleen, testis, fetal brain, amygdala, corpus callosum, cerebellum, thalamus and subthalamic nucleus of adult brain.
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数据库链接:
HGNC: 25931
OMIM: 139300
KEGG: hsa:84952
STRING: 9606.ENSP00000281282
UniGene: Hs.148989
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