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CEP70 Antibody

  • 货号：
    CSB-PA834525
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from COS cells, using CEP70 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CEP70 Polyclonal antibody
  • Uniprot No.：
    Q8NHQ1
  • 基因名：
    CEP70
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human CEP70.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
  • 基因功能参考文献：
    1. Cep70 interacts with tubulin, and promotes the ability of paclitaxel to stimulate microtubule assembly. These data demonstrate that Cep70 mediates paclitaxel sensitivity in breast cancer. PMID: 28632150
    2. these results demonstrate a critical role for Cep70 in the development and progression of breast cancer. PMID: 28063737
    3. Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization PMID: 26893288
    4. findings suggest that Cep70 promotes microtubule stability by interaction with HDAC6 and regulation of tubulin acetylation PMID: 26112604
    5. data showed that Cep70 increased the microtubule length without affecting the microtubule number in the purified system; results demonstrate that Cep70 could directly regulate microtubule assembly by promoting microtubule elongation instead of microtubule nucleation PMID: 22427462
    6. These results thus report for the first time the identification of Cep70 as an important centrosomal protein that interacts with gamma-tubulin and underscore its critical role in the regulation of mitotic spindle assembly. PMID: 21795687

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized at the center of the radial microtubule array in interphase and at the spindle poles during various stages of mitosis.
  • 数据库链接：

    HGNC: 29972

    OMIM: 614310

    KEGG: hsa:80321

    STRING: 9606.ENSP00000264982

    UniGene: Hs.531962