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CEP19 Antibody

  • 货号：
    CSB-PA850384LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA850384LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CEP19 Polyclonal antibody
  • Uniprot No.：
    Q96LK0
  • 基因名：
    CEP19
  • 别名：
    CEP19 antibody; C3orf34 antibody; HSD5 antibody; Centrosomal protein of 19 kDa antibody; Cep19 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Centrosomal protein of 19 kDa protein (1-163AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CEP19 Antibody (CSB-PA850384LA01HU)，的标记方式是Non-conjugated。对于CEP19 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA850384LB01HU CEP19 Antibody, HRP conjugated ELISA
    FITC CSB-PA850384LC01HU CEP19 Antibody, FITC conjugated
    Biotin CSB-PA850384LD01HU CEP19 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes.
  • 基因功能参考文献：
    1. RABL2 binds to CEP19 and the IFT74-IFT81 heterodimer in a mutually exclusive manner. PMID: 28428259
    2. CEP19 is recruited to the ciliary base by the centriolar CEP350/FOP complex and then specifically captures GTP-bound RABL2B, which is activated via its intrinsic nucleotide exchange. PMID: 28625565
    3. loss of the ciliary protein CEP19 in humans and mice causes morbid obesity. PMID: 24268657
  • 相关疾病：
    Morbid obesity and spermatogenic failure (MOSPGF)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    CEP19 family
  • 数据库链接：

    HGNC: 28209

    OMIM: 615586

    KEGG: hsa:84984

    STRING: 9606.ENSP00000387209

    UniGene: Hs.282800