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CEP135 Antibody

  • 货号：
    CSB-PA721063LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of A549 cells with CSB-PA721063LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CEP135 Polyclonal antibody
  • Uniprot No.：
    Q66GS9
  • 基因名：
  • 别名：
    centrosomal protein 135 kDa antibody; centrosomal protein 135kDa antibody; Centrosomal protein 4 antibody; Centrosomal protein of 135 kDa antibody; centrosome protein 4 antibody; centrosome protein cep135 antibody; Cep135 antibody; CEP4 antibody; CP135_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Centrosomal protein of 135 kDa protein (94-195AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CEP135 Antibody (CSB-PA721063LA01HU)，的标记方式是Non-conjugated。对于CEP135 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA721063LB01HU CEP135 Antibody, HRP conjugated ELISA
    FITC CSB-PA721063LC01HU CEP135 Antibody, FITC conjugated
    Biotin CSB-PA721063LD01HU CEP135 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.
  • 基因功能参考文献：
    1. CEP135 segment 96-108 is a major microtubule-binding site. PMID: 27477386
    2. identified the second mutation in CEP135, confirming the role during embryonic brain development and in the pathophysiology of human primary microcephaly PMID: 26657937
    3. s suggest that the decrease in CEP135(mini) from centrosomes promotes centriole assembly. The repression of centriole duplication by a splice isoform of a protein that normally promotes it serves as a novel mechanism to limit centriole duplication. PMID: 26412126
    4. These findings support a model in which PKC-mediated phosphorylation of CEP4 at Ser(18) and Ser(80) causes its dissociation from Cdc42, thereby increasing its affinity for TEM4 and producing Rac activation, filopodium formation, and cell motility PMID: 25086031
    5. s propose that CEP135 directly connects the central hub protein, hSAS-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP-mediated centriole elongation. PMID: 23511974
    6. A truncating mutation of CEP135 caused autosomal-recessive primary microcephaly in a Pakistani family. PMID: 22521416
    7. CEP135 acts as a platform protein for C-NAP1 at the centriole. PMID: 18851962

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  • 相关疾病：
    Microcephaly 8, primary, autosomal recessive (MCPH8)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles.
  • 蛋白家族：
    CEP135/TSGA10 family
  • 数据库链接：

    HGNC: 29086

    OMIM: 611423

    KEGG: hsa:9662

    STRING: 9606.ENSP00000257287

    UniGene: Hs.518767