CEP131 Antibody
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货号:CSB-PA000964
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规格:¥880
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图片:
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其他:
产品详情
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Uniprot No.:Q9UPN4
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基因名:CEP131
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别名:5 azacytidine induced 1 antibody; 5-azacytidine-induced protein 1 antibody; AZ1 antibody; Azi antibody; Azi1 antibody; AZI1_HUMAN antibody; Centrosomal protein 131 kDa antibody; Centrosomal protein of 131 kDa antibody; Cep131 antibody; KIAA1118 antibody; OTTMUSP00000004498 antibody; Pre-acrosome localization protein 1 antibody; RP23 37J21.1 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Synthesized peptide derived from the Internal region of Human AZI1.
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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产品提供形式:Liquid
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应用范围:WB, IHC, ELISA
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner. Acts also as a negative regulator of BBSome ciliary trafficking. Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells. Involved in centriole duplication. Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. Essential for maintaining proper centriolar satellite integrity.
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基因功能参考文献:
- CEP131 serves as a potential prognostic biomarker in HCC PMID: 28694105
- CEP131 is the key regulatory target of MK2 and 14-3-3 in centriolar satellite remodeling. PMID: 26616734
- These data therefore highlight the importance of human Cep131 for maintaining genomic integrity PMID: 22797915
- Analysis of the data suggested that SP1 is a pivotal transcription factor for the regulation of CEP131 expression, consequently leading the control of centrosome functions. PMID: 23137637
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亚细胞定位:Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasmic vesicle, secretory vesicle, acrosome.
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蛋白家族:CEP131 family
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数据库链接:
HGNC: 29511
OMIM: 613479
KEGG: hsa:22994
STRING: 9606.ENSP00000393583
UniGene: Hs.514578
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