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CEP120 Antibody

  • 货号：
    CSB-PA836696ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA836696ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA836696ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CEP120 Polyclonal antibody
  • Uniprot No.：
    Q8N960
  • 基因名：
    CEP120
  • 别名：
    CCDC100 antibody; CE120_HUMAN antibody; Centrosomal protein of 120 kDa antibody; Cep120 antibody; Coiled-coil domain-containing protein 100 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Centrosomal protein of 120 kDa protein (1-270AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.
  • 基因功能参考文献：
    1. The CEP120-associated phenotype ranges from mild classical JS in four patients to more severe conditions in two fetuses. PMID: 27208211
    2. We establish a novel locus for Jeune asphyxiating thoracic dystrophy on 5q23.2 by linkage analysis and demonstrate that a mutation in CEP120 within this locus is the most likely cause of the disease. PMID: 25361962
    3. Functional characterization of the homologous mouse gene, and comparison to the human protein. PMID: 17920017
  • 相关疾病：
    Short-rib thoracic dysplasia 13 with or without polydactyly (SRTD13); Joubert syndrome 31 (JBTS31)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    CEP120 family
  • 数据库链接：

    HGNC: 26690

    OMIM: 613446

    KEGG: hsa:153241

    STRING: 9606.ENSP00000303058

    UniGene: Hs.483209