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CENPM Antibody

  • 货号：
    CSB-PA437170
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA437170(CENPM Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA437170(CENPM Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9NSP4
  • 基因名：
    CENPM
  • 别名：
    CENPM antibody; C22orf18 antibody; ICEN39 antibody; PANE1Centromere protein M antibody; CENP-M antibody; Interphase centromere complex protein 39 antibody; Proliferation-associated nuclear element protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Full length fusion protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:10-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.
  • 基因功能参考文献：
    1. CENP-M is crucially required for the assembly and stability of a tetramer also comprising CENP-I, CENP-H, and CENP-K, the HIKM complex, which we extensively characterize through a combination of structural, biochemical, and cell biological approaches. PMID: 25006165
    2. Expression of the human PANE1 gene was detected preferentially in immune cells PMID: 15183305
    3. an alternative transcript of the proliferation-associated nuclear element 1 (PANE1) gene encodes a novel (HLA)-A(*)0301-restricted mHAg that is selectively expressed in B-lymphoid cells PMID: 16391015
    4. PANE1 localizes to the centromere throughout the cell cycle and its localization is dependent on the centromere specific histone variant CENP-A. PMID: 16622419
  • 亚细胞定位：
    Nucleus. Cytoplasm. Chromosome, centromere, kinetochore.
  • 组织特异性：
    Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 i
  • 数据库链接：

    HGNC: 18352

    OMIM: 610152

    KEGG: hsa:79019

    STRING: 9606.ENSP00000215980

    UniGene: Hs.208912