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CENPC Antibody

  • 货号：
    CSB-PA209620
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA209620(CENPC Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA209620(CENPC Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q03188
  • 基因名：
    CENPC
  • 别名：
    CENP-C 1 antibody; CENP-C antibody; CENPC_HUMAN antibody; CENPC1 antibody; Centromere autoantigen C antibody; Centromere autoantigen C1 antibody; Centromere protein C 1 antibody; Centromere protein C antibody; hcp-4 antibody; ICEN7 antibody; Interphase centromere complex protein 7 antibody; MIF2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human CENPC
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
  • 基因功能参考文献：
    1. Whereas CENP-C recruits a single MIS12:NDC80 complex, the s show here that CENP-T binds one MIS12:NDC80 and two NDC80 complexes upon phosphorylation by the mitotic CDK1:Cyclin B complex at three distinct CENP-T sites. PMID: 28012276
    2. CENP-C specifically binds alpha satellite non-coding RNAs. PMID: 28787590
    3. A nonhistone centromere protein, CENP-C, binds and reshapes the nucleosome, sliding the DNA gyres back to positions similar to those in canonical nucleosomes containing conventional histone H3. PMID: 26878239
    4. HPV18 E7 inhibited the binding of CENP-C to alpha-satellite DNAs. PMID: 25997930
    5. CENP-C recruits the Ndc80 complex through its interactions with KNL1 and the Mis12 complex at kinetochores during chromosome segregation. PMID: 25660545
    6. CENP-C, a CCAN subunit, is crucial for kinetochore assembly because it links centromeres with the microtubule-binding interface of kinetochores. PMID: 26124289
    7. CENP-C affects nucleosome shape and dynamics in a manner analogous to allosteric regulation of enzymes. CENP-C depletion leads to rapid removal of CENP-A from centromeres, indicating their collaboration in maintaining centromere identity. PMID: 25954010
    8. CENP-C works as an important factor for centromeric M18BP1 recruitment PMID: 22540025
    9. Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore. PMID: 21353556
    10. CENP-C may target the centromere by establishing multiple contacts with both the DNA and protein constituents of the kinetochore PMID: 12490152
    11. CENPC target sites that can be sumoylated by SUMO-2 were shown to be equally susceptible to SUMO-1 attachments which include specific sites on SUMO-2 itself, Ubc9, and the recombinant CENP-C fragments PMID: 15272016
    12. a functional interplay between the chromosomal passenger complex and CENP-C. PMID: 17287400
    13. Using protein truncation and in vitro mutagenesis, we have identified the nucleolar localization sequences on CENPC1,and evidence shows that CENPC1 is an RNA-associating protein that binds alpha-satellite RNA by an in vitro binding assay. PMID: 17623812
    14. CENP-C and CENP-H co-localize to the CENP-A chromatin domain. PMID: 17651496
    15. DNMT3B interacts with CENP-C to modulate DNA methylation and the histone code at centromere. PMID: 19482874
    16. C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation PMID: 19503796

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  • 亚细胞定位：
    Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere.
  • 蛋白家族：
    CENP-C/MIF2 family
  • 数据库链接：

    HGNC: 1854

    OMIM: 117141

    KEGG: hsa:1060

    STRING: 9606.ENSP00000273853

    UniGene: Hs.479867